Local Anesthetics

Question 1

List the Benzylisoquinolines

non depols

Answer 1

atracurium
cisatracurium
cisatracurium
tubocurarine

Question 2

List the ammonio steroids

nondepols

Answer 2

pancuronium
rocuronium
vecuronium

Question 3

which nondepol is short acting?

Answer 3

mivacurium

Question 4

which nondepol is intermediate acting

Answer 4

atracurium
cisatracurium
rocuronium
vecuronium

Question 5

which nondepol is long acting

Answer 5

tubocuraraine

pancuronium

Question 6

kidney excreted or liver excreted have longer half lives

Answer 6

kidney - longer

liver - shorter

Question 7

Name elimination mechanism for short acting mevacrium

Answer 7

plasma pseudcholinesterase

Question 8

Name elimiation for atracurium intermediate

Answer 8

enzymatic and non enzymatic –> laudanosine – hypotension and seizures

Question 9

Name elimination for intermediate cisatracurim

Answer 9

spontaneous and renal

Question 10

name elimianation for intermediate rocuronium

Answer 10

hepatic 80% and renal

Question 11

name elimination for vecuronium intermiediate

Answer 11

hepatic 80% and renal

Question 12

name elimination for long pancuronium

Answer 12

renal 80% and hepatic

Question 13

name elimination for long tubocurarine

Answer 13

renal and hepatic

Question 14

i say laudanosine you think this nondepol and then you’d replace it with this nondepol

Answer 14

atracurium (hydrolyzed by non specific plasma esterase; not effected at renal failure) –< laudanosine can cause hypotension and seizures –> replace with cisatracurium that produces less laudanosine

Question 15

how is mivacurium depol

Answer 15

only short acting

butyrylcholinesterase
not dependent on lvier or kidney

Question 16

which is the most rapid onset?

Answer 16

rocuronium

Question 17

a/se of benzylisoquinolines

Answer 17

hypotension bc they cause histamine release and ganglionic blockade

Question 18

a/se of ammonio steroids

Answer 18

tachycardia due to blockade of muscarnic receptors - arrhtymias

Question 19

i say histamine release and you think

Answer 19

benzyls

tubocurarine > mivacurium and atracurium

Question 20

i say ganglion blockated and you think

Answer 20

tubocurarine = hypotension and tachycardia

Question 21

i say blockade of cardiac M2 receptors and you think?

Answer 21

pancuronium - tachyca`rdia

Question 22

a/se of depol blocker

Answer 22

stimulates nicotinic and muscarinic receptors

• bradycardia
• histamine release
• muscle pain
• hyperkalemia
• increased IOP
• increased intragastric pressure

Question 23

who causese malignant hypertension and hwo do you treat it?

Answer 23

succinylcholine and haloperidol

tx with dan-tro-leenn

Question 24

Spasmolytics MOA mania: diazepam

Answer 24

facilitates action of GABA at GABAa receptors

Question 25

Spasmolytics MOA mania: baclofen

Answer 25

GABAb agonist

Question 26

Spasmolytics MOA mania: tizanidine

Answer 26

alpha 2 agonist in CNS

Question 27

Spasmolytics MOA mania: gabapentin

Answer 27

increases GABA release

Question 28

Spasmolytics MOA mania: progabide

Answer 28

GABAa and GABAb agonist

Question 29

Spasmolytics MOA mania: glycine

Answer 29

inhibitory aa neurotransmitter

Question 30

Spasmolytics MOA mania: idrocilamide and rilouzole

Answer 30

ALS

inhibit glutaminergic

Question 31

Spasmolytics MOA mania: dantrolene

Answer 31

malignant hyperthermia

prevents RYR from releasing Ca++

Question 32

Spasmolytics MOA mania: botulinnum

Answer 32

cerebral palsy

Question 33

cyclobenzaprine

Answer 33

muscle spasm from strain or truama