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Pharmacology > 2 NSAIDs > Flashcards

2 NSAIDs Flashcards

1
Q

Using NSADs causes damage to gastric barrier how?

A

Inhibition of COX-1

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2
Q

COX-2 is constitutive where?

A

Kidney and Brain

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3
Q

What is the primary source of vascular prostacyclin?

A

Endothelial COX-2

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4
Q

Idomethacin use?

A

Gout

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5
Q

All NSAIDs can be used to treat gout except which ones?

A

Aspirin
Salicyclates
Tolmetin

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6
Q

Why is not aspirin used for gout?

A
  • It inhibits urate excretion at low doses

- May increase risk of renal calculi at high doses

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7
Q

Tolmetin is ineffective for which arthritis?

A

Gout

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8
Q

Frequent use of aspirin is associated with a 50% DECREASE in the risk of what?

A

Colon Cancer

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9
Q

Niacin flushing is mediated by what?

A

Release of PGD2

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10
Q

Niacin flushing can be inhibited with what?

A

Aspirin

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11
Q

What is the DOC for closure of ductus arteriosus?

A

Indomethacin

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12
Q

What are the two mechanisms by which NSAIDs cause gastric damage?

A

1) Inhibition of COX-1 in gastric epithelial cells

2) Ulceration by local irritation of the gastric mucosa

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13
Q

Which drugs reduce the rick of gastric ulcer and are used in the treatment of gastric damage induced by NSAIDs

A

1) Misoprostol
2) PPI
3) H2 blockers

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14
Q

Which NSAID has the lowest risk of adverse GI effects?

A

Celecoxib

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15
Q

Which NSAIDs (3) are low risk for GI adverse effects?

A

1) Ibuprofen
2) Aspirin
3) Diclofenac

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16
Q

Which NSAIDs (2) are medium risk for GI adverse effects?

A

1) Naproxen

2) Indomethacin

17
Q

Which NSAID has the highest risk for adverse GI effects

A

Piroxicam

18
Q

How do NSAIDs cause adverse cardiovascular effects

A

Thought to be caused by NSAIDs upsetting the balance between TXA2 and PGI2

19
Q

What are the cardiovascular effects of NSAIDs?

A

1) Vasocontriction
2) Platelet aggregation
3) Thrombosis

20
Q

Which NSAIDs have more CV risk?

A

More COX-2 selective

21
Q

What is the only selective COX-2 inhibitor in the US?

A

Celecoxib

22
Q

How do NSAIDs affect the renal system? (3)

A

1) Decrease in Renal Blood Flow
2) Acute interstitial Nephritis
3) Analgesic Nephropahty

23
Q

Why is Aspirin unique?

A

It IRREVERSIBLY acetylates COX

24
Q

How does a low dose of aspirin affect platelets?

A

Production of PGI2 is relatively unaffected

25
Q

What happens when a person is given 1g or more of aspirin?

A

-Conjugation enzymes become saturated and zero-order kinetics are observed

26
Q

Why is not Acetaminophen not an NSAID?

A

Because it has no anti-inflammatory or antiplatelet effect

27
Q

What is the DOC for pain relief in osteoarthritis

A

Acetaminophen

28
Q

What is the DOC for short-term treatment of fever and minor pain during pregnancy

A

Acetaminophen

29
Q

What is the DOC for short-term treatment of fever and flulike symptoms

A

Acetaminophen

Pharmacology (70 decks)

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