13.1 Anti-Malarials

Question 1

What are the clinical application of Malarone?

Answer 1

Treatment & prophylaxis of P. falciparum

Question 2

What are the clinical applications of Inhibitors of Folate Synthesis?

Answer 2

• Chemoprophylaxis: only in combination. Proguanil +
chloroquine = no longer recommended

• Intermittent Preventive Therapy: high-risk patients
receive intermittent therapy regardless of infection status

• Treatment of chloroquine-resistant falciparum malaria
: pyrimethamine-sulfadoxine commonly used. DO NOT
use for severe malaria

Question 3

Which antimalarial is active against erythocytic shizonts of all human malaria parasites? (not active against liver stage)

Answer 3

Doxycycline

Question 4

What are the AE of Doxycycine?

Answer 4

• GI, candidal vaginitis, photosensitivity

• Discoloration & hypoplasia of teeth, stunting of
growth

• Fatal hepatotoxicity (in pregnancy)

• DO NOT use in pregnancy or children < 8y (FDA
Category D)

Question 5

Which antimalarial class is derived from qinghaosu plant?

Answer 5

Atemisinin

Question 6

What is the MOA of Artemisinin?

Answer 6

Appears to act by binding iron, breaking down peroxide
bridges leading to generation of free radicals that damage
parasite proteins.