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Pharmacology > 1.2 GI Drugs > Flashcards

1.2 GI Drugs Flashcards

1
Q

Which antimicrobials are used in treatment for H.Pylori? (4)

A

1) Clarithromycin
2) Amoxicillin
3) Metronidazole
4) Tetracycline

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2
Q

What combination of drugs are used for H.Pylori infection?

A

Triple therapy: 2 ABx + PPIs

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3
Q

Besides triple therapy, what other combo is used to treat H.Pylori

A

Bismuth + 2 ABx + PPI or rantidine

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4
Q

Which drugs are the mucosal protective agents? (3)

A

1) Sucralfate
2) Bismuth subsalicylate
3) Misoprostol

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5
Q

Which mucosal protective agent is a disaccharide and requires acid to be activated?

A

Sucralfate

(do not give with PPI’s or H2 blockers

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6
Q

How does misoprostol work as a mucosal protective agent?

A
  • PGE1 Analogue

- Decreases HCl secretion and increase mucin & bicarb production via activation of Gi therefore dec cAMP.

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7
Q

What is the mechanism of mucosal protective agents?

A

Polymerization and selective binding to necrotic tissue forms a physical barrier to acid

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8
Q

Which mucosal agent is approved for NSAID induced ulcers but has been replaced by H2 blockers and PPI’s?

A

Misoprostol

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9
Q

What are the adverse effects of misoprostol? (3)

A

1) Diarrhea
2) Abortion
3) Exacerbation of IBD

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10
Q

Which drugs are the prokinetic agents? (5)

A

1) Bethanechol
2) Neostigmine
3) Metoclopramide
4) Cisapride
5) Erythromycin

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11
Q

Which prokinetic agent stimulates ACh secretion?

A

Cisapride

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12
Q

What is the mechanism of action of Cisapride?

A

5-HT4 agonist

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13
Q

What is the MOA of Metoclopramide? (3)

A

1) 5-HT3 and D2 blocker

3) 5-HT4 = prokinetic

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14
Q

Which prokinetic agent is a Motilin receptor agonist?

A

Erythromycin

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15
Q

What is Erythromycin indicated for?

A

Gastric emptying before endoscopy

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16
Q

Which prokinetic agent can cause arrhythmias and should be avoided in patients with long QT syndrome?

A

Cisapride

17
Q

Which prokinetic agent may develop tolerance in gastroparesis?

A

Erythromycin

18
Q

Which prokinetic agent has adverse effects of galactorrhea, sedation, diarhea, and extrapyramidal symptoms

A

Metoclopromide

19
Q

Which prokinetic agent is indicated for pseudoobstruction in hospitalized patients?

A

Neostigmine

20
Q

Which prokinetic agent is indicated for Gastroparesis, and emesis associated with chemo.

A

Metoclopromide

Pharmacology (70 decks)

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