Hypothalamic and Pituitary Hormones 1.1

Question 1

MOA of Somatropin and Somatrem

Answer 1

Activates IGF-1 via JAK2/STAT signaling cascade

effects mediated by IGF-1

Question 2

Indication of Somatropin and Somatrem (6)

Answer 2

1) GH deficiency
2) Short stature and adiposity in children
3) Hypoglycemia (unopposed insulin)
4) Growth failure assoc with Noonan, Prader-Willi or Turner syndrome in peds.
5) Wasting in HIV pts
6) Short bowl syndrome

Question 3

Notable PK of Somatropin and Somatrem

Answer 3

CYP450 induction

Question 4

AE of Somatropin and Somatrem in children: (7)

Answer 4

1) Hypothyroidism
2) Gynecomastia
3) Intracranial hypertension
4) Scoliosis
5) Pancreatitis
6) Otitis Media (Turner Syndrome)
7) Diabetic syndrome

Question 5

AE of Somatropin and Somatrem in adults: (5)

Answer 5

1) Edema
2) Carpal Tunnel
3) Retinopathy
4) Myalgia
5) Arthralgia

Question 6

Somatropin and Somatrem is contraindicated in whom?

Answer 6

Patient’s with malignancy

Question 7

GHRH analog

Answer 7

Sermorelin

Question 8

MOA of Sermorelin?

Answer 8

Stimulates release of GH

Question 9

AE of sermorelin?

Answer 9

Same as Somatropin

Question 10

Fun fact about sermorelin?

Answer 10

Does not work in patients with defective anterior pituitary

Question 11

Mecasermin is a?

Answer 11

IFG-1 analog

Question 12

MOA of Mecasermin

Answer 12

Needs to be combined with IGF-1 binding protein 3 to see clinical effects

Question 13

Indication of Mecasermin (3)

Answer 13

1) Growth failure due to decreased IGF-1
2) GH receptor mutation
3) Neutralizing anti-GH antibody

Question 14

AE of Mecasermin (3)

Answer 14

1) Hypoglycemia
2) Intracranial HTN
3) Increased liver enzymes