Hypothalamic and Pituitary Hormones 1.2

Question 1

GH receptor antagonist

Answer 1

Pegvisomant

Question 2

MOA of pegvisomant

Answer 2

Prevents dimerization

Question 3

Indication of Pegvisomant

Answer 3

Small GH secreting tumor

Question 4

Octreotide action is mediated by?

Answer 4

Disulfide bridge between cysteine residues

Question 5

MOA of Octreotide?

Answer 5

Inhibits release of GH, glucagon , insulin and gastrin

Question 6

Indication of Octreotide?

Answer 6

1) Reduce symptoms of hormone secreting tumors (acromegaly, carcinoid, gastrinoma etc)
2) Localize neuroendocrine tumors
3) Control variceal bleeding

Question 7

AE of Octreotide (7)

Answer 7

1) Nausea and Vomiting
2) Steatorrhea
3) Constipation
4) Gallstones
5) Pain at injection sites
6) Sinus bracycardi
7) B12 Deficiency

Question 8

Bromocriptine

Cabergoline

Answer 8

• Dopamine agonist

- Inhibit prolactin and GH secretion.

Question 9

MOA of Bromocriptine & Cabergoline

Answer 9

Activates post synaptic dopamine receptors

Question 10

Indication of Bromocriptine & Cabergoline (2)

Answer 10

1) Prolactinoma

2) Acromegaly (in combination with surgery, radiation or octreotide)

Question 11

Half life of Cabergoline

Answer 11

65 hours

Question 12

Half life of Bromocriptine

Answer 12

7 hours

Question 13

AE of Bromocriptine/Cabergoline

Answer 13

1) Nausea, Headache, Lightheadedness
2) Orthostatic hypotension, fatigue
3) Psych manifestations
4) High dose leads to cold induced peripheral vasospasms
5) Pulmonary infiltrates

Question 14

Menotropins

Answer 14

Purified FSH & LH

Question 15

Purified FSH

Answer 15

Follitropin

Urofollitropin