15.1 Anticancer

Question 1

What drugs are given for Hodgkin’s Lymphoma

Answer 1

–A-Adriamycin (Doxorubicin)
–B-Bleomycin
–V-Vincristine
–D-Dacarbazine

Question 2

What anticancer drugs do not cause bone marrow suppression? (2)

Answer 2

1) Bleomycin

2) Vincristine

Question 3

Which drugs are used for testicular cancer?

Answer 3

–B-Bleomycin
–E-Etoposide
–P-Platinum (Cisplatin)

Question 4

What is adjuvant chemotherapy?

Answer 4

Chemotherapy is added in addition to surgery or radiotherapy

Question 5

What is Neo-adjuvant chemotherapy?

Answer 5

Chemotherapy given before surgery to decrease the size of tumor.

Question 6

What is induction chemotherapy?

Answer 6

chemotherapy given to obtain complete remission from the tumor, usually blood cancers.

Question 7

What is maintenance chemotheraphy?

Answer 7

chemotherapy given to maintain remission from the cancer

Question 8

Alkylation occurs where?

Answer 8

Alkylation at N7 position of guanine in DNA

Question 9

Cyclophosphamide metabolims gives a toxic compound called what?

Answer 9

Acrolein

Question 10

What inactivates acrolein?

Answer 10

MESNA

Question 11

What is Ifosfamide?

Answer 11

• Mechanism of action & ADR similar to cyclophosphamide
• More potent than cyclophosphamide
• More potential to cause hemorrhagic cystitis
• Prior administration of MESNA is a must for each dose

Question 12

Which alkylating agents cross the BBB?

Answer 12

Nitrosoureas

highly lipophyllic