Hypothalamic and Pituitary Hormones 2.2

Question 1

Clinical application of Vasopressin (2)

Answer 1

1) Esophageal variceal bleeding

2) Colonic diverticular bleeding

Question 2

Clinical application of Desmopressin (2)

Answer 2

Coagulopathy treatment in

1) Hemophilia A
2) von Willibrand’s disease

Question 3

A.E. due to overdosage of Vasopressin agonist (2)

Answer 3

1) Hyponatremia

2) Seizures

Question 4

Vasopressin antagonist

Answer 4

Conivaptan

Question 5

Conivaptan clinical use

Answer 5

Patients with hyponatremia (due to elevated vasopressin)

Question 6

Conivaptan has high affinity for?

Answer 6

V1 and V2 receptors of ADH