12.0 Antiparasitic Drugs

Question 1

Which are the mixed antiamebics?

Answer 1

Metronidazole

Tinidazole

Question 2

What is the DOC for treating amebosiasis?

Answer 2

Metronidazole

Question 3

What is the MOA of Metronidazole?

Answer 3

• Once absorbed, metronidazole is non-enzymatically

reduced by reacting with reduced ferredoxin

Question 4

What are the most important AE from Metronidazole?

Answer 4

GI distress
Disulfiram-like rxn
Unpleasant metallic taste

Question 5

What are the Luminal Antiamebics?

Answer 5

• Diloxanide furoate
• Iodoquinol
• Paromomycin

Question 6

What are the systemic antiamebics?

Answer 6

• Chloroquine
• Emetine
• Dehydroemetine

Question 7

Which drug class is useful for treating liver abscesses or intestinal wall infections?

Answer 7

Systemic Antiamebics

Question 8

Which drugs are in the Benzimidazoles?

Answer 8

• Albendazole
• Mebendazole (most common)
• Thiabendazole

Question 9

Mebendazole is the DOC for what?

Answer 9

• Whipworm (Trichuris trichiura)
• Pin worm (Enterobius vermicularis)
• Hookworms (Necator americanus &
Ancylostoma duodenale)
• Roundworm (Ascariasis lumbricoides)

Question 10

Which benzimidazole is the most toxic?

Answer 10

Thiabendazole

Question 11

What is the MOA of Ivermectin?

Answer 11

• GABA agonist
• Cl- influx increases leading to hyperpolarization of nerve /
muscle cell. Death occurs due to paralysis of parasite

Question 12

Ivermectin in contraindicated in what?

Answer 12

Pregnancy
Meningitis
Avoid combination with other drugs that enhave GABAergic activity

Question 13

Which drug has activity against Wuchereria bancrofti?

Answer 13

Doxycycline

Question 14

What is Praziquantel the DOC for?

Answer 14

• of Drug choice for all forms of schistosomiasis & most trematode & cestode infections

Question 15

What is the DOC for fasciolosis?

Answer 15

Bithionol