Oxyhemoblobin Dissociation Curve Flashcards
What are the two ways oxygen comes into the body?
- Dissolved in plasma
2. Bound to hemoglobin
What is the most common way that oxygen comes into the body?
Bound to hemoglobin (98.5% of the total O2 transported)
What determines the binding and release of O2 from hemoglobin?
PO2
What shows the relationship between oxygen binding and releasing from hemoglobin?
oxy-hemoglobin dissociation curve
What does the percent saturation of hemoglobin mean?
the greater % of hemoglobin –> the greater % of O2 bc hemoglobin holds O2
What parts of the body have a high hemoglobin saturation?
Lungs
What parts of the body have low hemoglobin saturation?
muscles ex: thigh muscle
What changes oxygen’s attraction to hemoglobin
pH, temperature and CO2
What causes a RIGHT shift in the oxyhemoglobin dissociation curve
low pH
high temperature
high PCO2
what is a right shift in the curve called?
Bohr shift
Does a right shift increase or decrease oxygen’s affinity for hemoglobin?
decreases
What does a decrease in affinity for hemoglobin mean?
Blood will release oxygen more readily
What causes a left shift in the oxyhemoglobin dissociation curve?
high pH
low temperature
low PCO2
What does a left shift cause between oxygen and hemoglobin?
increased affinity = oxygen will hold on the hemoglobin and not be released
During a right shift, where will oxygen be released more readily by hemoglobin?
tissue capillaries
