Citric Acid Cycle Enzymes and Products German 9/22/16 Flashcards

1
Q

What is the first step of the Citric Acid Cycle (CAC)?

A

Go from Acetyl-CoA + oxaloacetate to Citrate

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2
Q

What enzyme is responsible for converting Acetyl-CoA + oxaloacetate to Citrate?

A

Citrate synthase

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3
Q

What is the second step of the CAC?

A

Go from Citrate to Isocitrate

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4
Q

What enzyme is responsible for converting citrate to isocitrate?

A

aconitase

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5
Q

What is the third step of the CAC?

A

Go from Isocitrate to Alpha-Ketoglutarate

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6
Q

What enzyme is responsible for converting isocitrate to Alpha-ketoglutarate?

A

Isocitrate dehydrogenase

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7
Q

What is a byproduct when you go from isocitrate to Alpha-ketogluatarate?

A

CO2

NADH

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8
Q

What is the fourth step of the CAC?

A

Go from Alpha-keotglutarate to succinyl-CoA

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9
Q

What is the enzyme responsible for converting alpha-ketoglutarate to succinyl-CoA?

A

Alpha-ketoglutarate dehydrogenase complex

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10
Q

What is a byproduct when you go from alpha-ketoglutarate to succinyl-CoA?

A

CO2

NADH

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11
Q

What is the fifth step of the CAC?

A

Go from Succinyl-CoA to Succinate

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12
Q

What enzyme is responsible for converting succinyl-CoA to succinate?

A

Succinyl-CoA synthetase

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13
Q

What is a byproduct when going from succinyl-CoA to succinate?

A

ATP (GTP)

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14
Q

What is the sixth step of the CAC?

A

Go from Succinate to Fumarate?

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15
Q

What is the enzyme responsible for converting succinate to fumarate?

A

Succinate Dehydrogenase

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16
Q

What is a byproduct when you go from succinate to fumarate?

A

FADH2

17
Q

What is unique about Succinate Dehydrogenase?

A

It is found in the Electron Transport chain complex in the inner membrane of the mitochondria

18
Q

What is the seventh step of the CAC?

A

Go from fumarate to Malate

19
Q

What enzyme is responsible for converting fumarate to malate?

A

Fumarase

20
Q

What is the eighth step of the CAC?

A

Go from Malate to Oxaloacetate

21
Q

What is the enzyme responsible for converting malate to oxaloacetate?

A

Malate dehydrogenase

22
Q

What is a byproduct when going from malate to oxaloacetate?

A

NADH

23
Q

T/F Energy substrates/products allosterically regulate enzymes in the CAC

A

True

24
Q

T/F The CAC is not regulated by mass action.

A

False

It is regulated by mass action

25
Q

What can alpha-ketoglutarate be converted into outside of the CAC?

A

Glutamate

26
Q

T/F Pyruvate can enter the CAC cycle at different places

A

True

27
Q

T/F The CAC is an important synthetic pathway

A

True

28
Q

What is the primary excitatory amino acid?

A

Glutamate