Cardio Pharmacology (HF) (Exam 3) Flashcards
RAAS inhibitors in HF
ACE
ARBS
ARNI
(Never on all 3) (Never take multiple RAAS inhibitors)
ARNI
Angiotensin Receptor Neprilysin Inhibitor
sacubitril/valsartan
Has NEPRILYSIN INHIBITOR (prevent cardiac remodling)
RASS inhibitors: MOA
Decrease preload and Decrease afterload
Suppresses aldosterone and stops cardiac remodeling
RAAS: Adverse effects
Hypotension and increase potassium
carvedilol: MOA
Beta and Alpha Blockade
Protect against SNS activation
Dysrhythmias
Reverse cardiac remodeling
carvedilol: Adverse Effects
Hypotension
Bradycardia
Fluid retention or worsening HF
Mineralocorticoid Receptor Antagonsit
Spironolactone
Helps suppress sodium/water retention to help with OFFLOADING of the LV
Spironolactone: MOA
Helps suppress sodium/water retention to help with OFFLOADING of the LV
Watch for hyperkalemia
SLG2 Inhibitors and HF
Dapagliflozin
Dapagliflozin: MOA
Ventricular unloading through osmotic diuresis with depleting volume
Decreases Readmission
Diuretics in HF
Furosemide = 1st line therapy
Watch for potassium imbalances
NO SURVIVAL BENEFIT
Furosemide: Adverse Effects
Hypokalemia
Hypotension
Digoxin toxicity
Inotropic Drugs
(HEART PUMP HARDER) (INCREASE CONTRACTILITY)
Cardiac glycoside: Digitalis
Sympathomimetics: Dopamine and dobutamine
digitalis/digoxin: Class
Cardiac glycoside: Inotropic agent
digitalis/digoxin: MOA
Inhibits sodium-potassium ATP pump causing calcium to collect within the cells of the heart helping to increase myocardial contractility
Increase blood flow to the kidney
helping to excretion of sodium and water
Decrease sympathetic action and increase parasympathetic action = Decrease HR
digitalis/digoxin: Adverse Effects
Cardiac Dysrhythmias
Digitalis Toxicity
Digitalis Toxicity: Who is at risk
Older
Women
Digoxin and diuretic therapy
Preventing Digitalis Toxicity
Reduce the dose
Monitor serum levels
Supplemental potassium
Nursing Implication when giving digoxin
Monitor serum potassium levels (we do not want them to be low) (HF patients are at risk because they are on diuretics)
What does digitalis toxicity look like?
Bradycardia
Headache
Dizziness
Confusion
Nausea
Visual disturbances - Blurry/ yellow vision
Patient education digoxin / digitalis toxicity
Take apical pulse for a full minute prior to administering digoxin
Hold if pulse below 60 bpm
What is the antidote for digitalis toxicity?
Digoxin immune Fab (Digibind) Given IV