Cardio Pharmacology (HF) (Exam 3) Flashcards

1
Q

RAAS inhibitors in HF

A

ACE

ARBS

ARNI

(Never on all 3) (Never take multiple RAAS inhibitors)

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2
Q

ARNI

A

Angiotensin Receptor Neprilysin Inhibitor

sacubitril/valsartan

Has NEPRILYSIN INHIBITOR (prevent cardiac remodling)

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3
Q

RASS inhibitors: MOA

A

Decrease preload and Decrease afterload

Suppresses aldosterone and stops cardiac remodeling

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4
Q

RAAS: Adverse effects

A

Hypotension and increase potassium

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5
Q

carvedilol: MOA

A

Beta and Alpha Blockade

Protect against SNS activation
Dysrhythmias
Reverse cardiac remodeling

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6
Q

carvedilol: Adverse Effects

A

Hypotension

Bradycardia

Fluid retention or worsening HF

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7
Q

Mineralocorticoid Receptor Antagonsit

A

Spironolactone

Helps suppress sodium/water retention to help with OFFLOADING of the LV

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8
Q

Spironolactone: MOA

A

Helps suppress sodium/water retention to help with OFFLOADING of the LV

Watch for hyperkalemia

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9
Q

SLG2 Inhibitors and HF

A

Dapagliflozin

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10
Q

Dapagliflozin: MOA

A

Ventricular unloading through osmotic diuresis with depleting volume

Decreases Readmission

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11
Q

Diuretics in HF

A

Furosemide = 1st line therapy

Watch for potassium imbalances

NO SURVIVAL BENEFIT

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12
Q

Furosemide: Adverse Effects

A

Hypokalemia

Hypotension

Digoxin toxicity

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13
Q

Inotropic Drugs

A

(HEART PUMP HARDER) (INCREASE CONTRACTILITY)

Cardiac glycoside: Digitalis

Sympathomimetics: Dopamine and dobutamine

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14
Q

digitalis/digoxin: Class

A

Cardiac glycoside: Inotropic agent

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15
Q

digitalis/digoxin: MOA

A

Inhibits sodium-potassium ATP pump causing calcium to collect within the cells of the heart helping to increase myocardial contractility

Increase blood flow to the kidney
helping to excretion of sodium and water

Decrease sympathetic action and increase parasympathetic action = Decrease HR

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16
Q

digitalis/digoxin: Adverse Effects

A

Cardiac Dysrhythmias

Digitalis Toxicity

17
Q

Digitalis Toxicity: Who is at risk

A

Older

Women

Digoxin and diuretic therapy

18
Q

Preventing Digitalis Toxicity

A

Reduce the dose

Monitor serum levels

Supplemental potassium

19
Q

Nursing Implication when giving digoxin

A

Monitor serum potassium levels (we do not want them to be low) (HF patients are at risk because they are on diuretics)

20
Q

What does digitalis toxicity look like?

A

Bradycardia

Headache

Dizziness

Confusion

Nausea

Visual disturbances - Blurry/ yellow vision

21
Q

Patient education digoxin / digitalis toxicity

A

Take apical pulse for a full minute prior to administering digoxin

Hold if pulse below 60 bpm

22
Q

What is the antidote for digitalis toxicity?

A

Digoxin immune Fab (Digibind) Given IV