Antimicrobials pt. 1 (Exam 1a.)

Question 1

Antibiotics that inhibit or damage cell wall synthesis

Answer 1

Penicillins

Cephalosporins

Carbapenems

Vancomycin

Question 2

Beta Lactam Antibiotics

Answer 2

Antibiotics that have a beta lactam structure

Penicillins, Cephalosporins, Carbapenems, and monobactams

If bacteria produces BETA - Lactamase, these types of antibiotics will NOT kill them. So we will combine 2 drug types to combat this issue

Sulbactam, clavulanic acid, tazobactam, avibactam (Beta-Lactam Antibiotics)

Question 3

Penicillin

Answer 3

-Naturally occuring mold

-Disrupt the synthesis of the cell wall

-Bacteria must be growing and dividing

-Inhibits transpeptidases

-Works against many different organisms

Question 4

CRE: Deadly Public Health Emergency

Answer 4

-Carbapenem-resistant Enterobacteriaceae

-Healthcare-acquired infection that usually kills 50% mortality in some patients

-BE very careful and do not spread. Carbapenem drugs are the broadest spectrum drugs we have so if they do not work we are cooked

Question 5

When do you draw a Peak?

Answer 5

15-30 min after intravenous administration

Question 6

When do you draw a trough?

Answer 6

Lowest concentration of drug in the system. 30 min prior to the next dose administration

Question 7

Transcription

Answer 7

-Nucleus

-Messenger RNA

-Cytoplasm

Question 8

Translation

Answer 8

Cytoplasm

Ribosomse (mRNA)

Add amine acids

Protein synthesis