45. Atopy Flashcards
definition of atopy
genetically inherited predisposition to anaphylactic or allergic diseases
dog atopy name
CAD - canine atopic dermatitis
what is the hereditary aspect of CAD
disposition to develop pruritic inflammatory skin disease associated with IgE antibodies
what do IgE antibodies target
typically environmental allergens
predisposition to CAD
dogs > cats
6months - 3yrs
westie
lab
g shepherd etc
clinical signs of feline atopy
generalised pruritus
miliary dermatitis like lesions
symmetric alopecia
facial pruritis
prurititc ears
indolent ulcer
pathogenesis of feline atopy
- Percutaneous sensitisation to environmental allergens and/or allergens from food
- Induced skin infiltration by various inflammatory cells
- Activation of resident cells
- Local production of inflammatory/itch mediators
allergens
ectoparasites - fleas
environmental factors
cutaneous bacterial colonisation or infection
epidermal barrier dysnfunction
environmental allergens
mites
dander
pollen
fungi
mould
feathers
forms of atopy
atopic dermatitis
atopic rhinitis
atopic conjunctivitis
clinical signs of atopy
pruritus
secondary skin lesions
seborrhoea
lichenification
erythema
pyoderma
papules
diagnosis of atopy
nb to exclude differentials
what to establish if you suspect CAD
age of onset
seasonality of clinical signs
pruritis with no skin changes at onset
family/ breed
previous response to gcc
contraindication of allergy testing
for diagnosing CAD
allergy testing types
intradermal skin testing
IgE testing
criteria for atopy facts
favrot’s criteria
need 5/8 fulfilled
8 criteria
Onset of signs < 3 years of age
Dog living mostly indoors
Glucocorticoid-responsive pruritis
Pruritis sine materia at onset (Ø dermatitis)
Affected front feet
Affected ear pinnae
Non-affected ear margins
Non-affected dorsolumbar area
treatment of cad
requires multifocal approach to decrease pruritus and inflammation
ID flare factors
use topical or systemic treatment to decreased p and i
flare factor examples
fleabite hypersensitivity
bacterial overgrowth
environmental allergens
fleas
yeast overgrowth
food allergens
symptomatic treatment of atopy
gcc and pred long term
cyclosporine
apoquel - oclacitinib
topical treatment of atopy
shampoo, spray, spot on, cream , gel
other treatment of atopy
antihistamine
vitamins
essential FAs
non - specific immunotherapy
desensitisation - allergy vaccines
