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SAM Final > 40. Infectious central nervous diseases > Flashcards

40. Infectious central nervous diseases Flashcards

1
Q

Viral CNS diseases

A

Canine Distemper
Rabies
Pseudorabies
Feline Borna Disease
Tick encephalitis
FIP
FIV
Canine Herpes
Feline Parvo
WNV

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2
Q

Canine Distemper virus name

A

Morbilivirus - paramyxoviridae

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3
Q

Clinical signs of Canine Distemper
(polysystemic signs)

A

Apathy
Mucopurulent discharge
Hyperkeratosis
DIarrhoea
Cough
Fever

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4
Q

Clinical signs of Canine Distemper
(neurological signs )

A

Brainstem signs
Cerebellar signs
Seizures
Circling
Myoclonus
Hyperkinesia
Ataxia
Menace deficit
VIsual impairement
Head depressing

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5
Q

Diagnosis of Canine Distemper

A

PCR urine
Conjunctival / bronchial smear- – inclusion bodies
IF test

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6
Q

Rabies virus name

A

Lyssavirus - rhabdoviridae
ZOOTNOTIC

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7
Q

Infection of Rabies

A

Transdermal Inoculation via wounds
Infectious material in contact with mucosa/ skin lesions
Virus cannot penetrate intact skin

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8
Q

Incubation of Rabies

A

2-3months

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9
Q

Pathophy of Rabies

A

Virus —> cns via retrograde axoplasmic transport
replication –> pathological effect on nerve cells
peripheral nerves –> adjacent non nervous tissue
dissemination throughout body

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10
Q

Clinical signs of Rabies
initially

A

Not eating or drinking
vomitus
anorexia
lethargy
fever

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11
Q

Clinical signs of Rabies
later

A

Cranial nerve dysfunction
weakenss
dyspnoea
abnormal behaviour
excessive salivation
ataxia
paralysis
seizures
dysphagia
aggression

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12
Q

Forms of Rabies

A

Furious and paralytic

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13
Q

Death in case of Rabies

A

Within 6 days of clinical signs

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14
Q

Diagnosis of Rabies

A

PM only
Brain histology is NB - inclusion bodies, inflammation

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15
Q

Differential of Rabies

A

Pseudorabies

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16
Q

another name for Pseudorabies

A

Aujeszky’s disease

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17
Q

Pseudorabies virus name

A

Varicellovirus - herpesviridae

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18
Q

Incubation of Pseudorabies

A

3-6days

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19
Q

Clinical signs of Pseudorabies

A

Ptyalism
restlessness
anorexia
vomiting
fever
incoordination
furious scratching
muscle spasms
rubbing
vocalisation
self mutilation

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20
Q

diagnosis of Pseudorabies

A

history
clinical signs
course

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21
Q

Prognosis of Pseudorabies

A

Bad
usually leads to death

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22
Q

Feline Borna Disease virus name

A

Orthobornavirus - - -bornaviridae

23
Q

another name for Feline Borna Disease

A

staggering disease
non suppurative meningoencephalomyelitis

24
Q

Transmission of Feline Borna Disease

A

Not readily transmitted
ticks are vectors
shrew act as reservoir host

25
Q

Clinical signs of Feline Borna Disease

A

gait disturbance
ataxia
pain in lower back
behavioural changes

26
Q

Diagnosis of Feline Borna Disease

A

RT - PCR

27
Q

Tick encephalitis virus name

A

flavirus - - flaviviridae

28
Q

Clinical signs of Tick encephalitis

A

Convulsions
Strbismus
Excitement
facial paralysis
Proprioceptive disorders
aggression
sensation disorder
anisocoria
fever
apathy
ataxia
paraplegia
tremor
nystagmus
mydriasis

29
Q

Lab d of Tick encephalitis

A

Leukopenia
Lymphopenia
monocytosis

30
Q

Treatment of Tick encephalitis

A

symptomatic

31
Q

FIP virus name

A

alphacoronavirus —- coronaviridae

32
Q

What is FIP associated with

A

dry granulomatous FIP
immune complex vasculitis

33
Q

What structures does FIP affect

A

primary intracranial and spinal cord

34
Q

Clinical signs of FIP

A
  • Motoric disorder
  • Tremor
  • Cerebellar ataxia
  • Stupor
  • HL paralysis
  • Dementia
  • Aggressiveness
  • Mydriasis
  • Nystagmus
  • Anisocoria
  • Anterior uveitis
  • Chorioretinitis
35
Q

How is the CNS protected from bacteria

A

BBB

36
Q

Aetiology of Bacterial CNS diseases

A

direct invasion
local source invasion
haematogenous invasion

37
Q

General clinical signs of Bacterial CNS diseases

A

Cervical hyperaesthesia
altered mental state
imbalance
paralysis
fever
ataxia
paresis

38
Q

Diagnosis of Bacterial CNS diseases

A

CSF examination

39
Q

Treatment of Bacterial CNS diseases

A

AB - ampicillin, enrofloxacin, metronidazole
GCC

40
Q

Listeria monocytogenesis invasion via

A

oral mucosa lesions

41
Q

Clinical signs of listeria

A

laryngeal paralysis
vestibular signs
circling
ataxia

42
Q

Treatment of listeria

A

doxycyclin

43
Q

Protozoal CNS diseases

A

Toxoplasma gondii
neospora caninum

44
Q

Toxoplasma gondii
host

A

cat

45
Q

Clinical signs of Toxoplasma gondii

A

Lethargy
penumonia
hyperextended HL
anorexia
lethargy
CNS signs

46
Q

Toxoplasma gondii inflammation

A

encephalitis
myelitis
peripheral neuropathies
myositis

47
Q

neospora caninum host

A

dog

48
Q

Transmission of neospora caninum

A

can be vertial in uterus

49
Q

neospora caninum inflammation

A

encephalitis
myelitis
peripheral neuropathies
choriomeningitis
myositis

50
Q

Treatment of neospora caninum

A

Clindamycin
potentiated sulphonamides

51
Q

Fungal CNS diseases

A

Cryptococcus
coccidioides
blastomyces
histoplasma
aspregillus

52
Q

Diagnosis of Fungal CNS diseases

A

CSF

53
Q

treatment of Fungal CNS diseases

A

Fluconazole
Flucytosine
must cross BBB

SAM Final (48 decks)

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