44. Allergodermatitis (without atopy) Flashcards
History & signalment of dermatological exam
exercise intolerance
repro status
appetite
PU/ PD
Physical dermatological exam
systemic disease
dermatological problem
dermatological exam
localise and describe lesion
ectoparasites
characteristics of hair / skin
addictional diagnostic methods for dermatological exam
skin scraping
otoscope
biopsy
immunology tests
Aetiological classification of skin disease
congenital
bacterial
normergic dermatitis
autoimmune
ectoparasites
allergiv
fungal
neoplastic
endocrine
other
what is most important when treating allergodermatitis
to treat more than just the allergy
16 types of
Allergodermatitis
Atopic Dermatitis
Adverse food reaction
pruritus
allergy and hypersensitivity
immune mediated disorders
urticaria
angioedema
atopic like dermatitis
Flea bite hypersensitivity
contact dermatitis
feline psychogenic alopecia
feline miliary dermatitis
feline eosinophilic granuloma complex
autoimmune disroders
discoid lupus erythematosus
systemic lupus erythematosus
another name for Atopic Dermatitis
eczema
which allergodermatitis is most common
Atopic Dermatitis
what is Atopic Dermatitis characterised by
itchy
red
swollen & cracked skin
diagnosis of Atopic Dermatitis
exclusion
how common is Adverse food reaction
20% of cases
cause of Adverse food reaction
one or more proteins in food provokes allergies
type 1, 2, 4
Clinical signs of Adverse food reaction
gi signs
Dog - pruritus, seborrhea, urticaria
Cat - generalised pruritus, miliary dermatitis - like lesions, facial dermatitis, eosinophil plaque / granuloma
Diagnosis of Adverse food reaction
elimination trial
only give one protein at a time to figure out the cause of allergy
IgE testing
Treatment of Adverse food reaction
allergen avoidance
hypoallergenic diet
associated clinical signs of pruritus
alopecia
dermatitis
inflammation
hyperpigmentation
hot spot
redness
crusts
dandruff
Causes of pruritus
allergy
ectoparasite
infection
neoplasia
immune mediated
syringomyelia
diagnosis of pruritus
history - intensity, progression, diet, environment
physical exam - lesions, localisation, symmetry
skin scraping
blood test - sacoptes
elimination of contact dermatitis
elimination diet
allegy tests
skin biopsy
differential of pruritus
self mutilation
excessive licking
foreign body
treatment of pruritus
apoquel (oclacitinib)
cytopoint (lokivetmab)
cyclosporin
side effects of apoquel
skin nodule
side effect of cyclosporin
can be emetic
contrainficated in neoplasia and in cats with toxoplasma
allergy definition
hypersensitivity of immunological origin
atopy definition
predisposition to develop an allergic reaction
pseudoallergy definition
allergy which is non specific or non immunological
allergen definition
non infectious
non invasive
innocuous
immune mediated disorders
anaphylaxis
cytotoxic
immune complex
cell mediated
possible cause of anaphylaxis
urticaria
angiooedema
allergic dermatitis
atopy
possible causes of cytotoxic
pemphigus
drug
AIHA
foetal erythroblastosis
possible causes of immune complex
SLE
glomerulonephritis vasculitis
drugs
possible causes of cell mediated
allergic
autoimmune
catact allergen
urticaria
type I & III hypersensitivity reaction
acute onset
causes of urticaria
drugs
vaccine
insect bites
clinical signs of urticaria
localised / generalised wheals
hairs stand up over affected area
variable pruritus
treatment of urticaria
water soluble
gcc
antihistamines
angioedema
type I hypersensitivity
cause of angioedema
wasp and bee sting
clinical signs of angioedema
extreme swelling of head, face and feet
laryngeal oedema
treatment of angioedema
adrenaline
gcc
tracheotomy if necessary
atopic like dermatitis
inflammatory & pruritic skin disease with similar clinical signs to atopic dermatitism
no IgE response to allergens
Flea bite hypersensitivity
Flea Allergy Dermatitis - FADA
Type I & IV hypersensitivity
Predisposed to FAD
dog > cat
seasonal
FAD in dogs
usually presents as papular dermatitis on flank, ventral abdomen or caudal body
may produce - lichenification, acral lick granuloma, pyotraumatic dermatitis, seborrhea, alopecia, crusting
secondary infections with yeast and bacteria
FAD in cats
miliary dermatitis
symmetrical alopecia
excoriations
eosinophilic granuloma complex
intense and constant pruritis
Diagnosis of FAD
flea dirt
therapeutic trial
Treatment of FAD
educate the owner
treat pruritis
prevent secondary infections
topical antiinflammatories
gcc - pred
predisposition to contact dermatitis
any age
some genetic disposition
dogs with weakened immune status
forms of contact dermatitis
allergic - contact dermatitis, immune system over reacts
irritant - contact dermatitis, direct damage to skin
contact hypersensitivity
rare delayed type IV hypersensitivity
cause of contact hypersensitivity
soap
pollen
disinfectant
shampoo
rubber
plastic
clinical signs of contact hypersensitivity
erythema
macules
disinfectant
hyperpigmentation
pruritis
diagnosis of contact hypersensitivity
scratch / patch testing
primary irritant contact dermatitis
must be differentiated from contact hypersensitivity
cause of primary irritant contact dermatitis
acids
alkalis
detergents
soaps
solvents
Clinical signs of primary irritant contact dermatitis
localisation where hair is sparse
red rash
pruritis
treatment of primary irritant contact dermatitis
bathing
topical gcc ointment
feline psychogenic alopecia
caused by anxiety neurosis
excessive licking & grooming
clinical signs of feline psychogenic alopecia
excessive licking & grooming
increased anxiety, nervousness
alopecia with no underlying inflammation
hairs at the affected site are broken
treatment of feline psychogenic alopecia
environmental enrichment
phermone products
clomipramine
fluoxetine
forms of feline eosinophilic granuloma complex
indolent ulcer
eosinophilic plaque
eosinophilic granuloma
indolent ulcer form of feline eosinophilic granuloma complex
raised border
swelling
eosinophilic plaque form of feline eosinophilic granuloma complex
demarcated
flat swellings of skin
reddened appearance
alopecia
pruritis
eosinophilic granuloma form of feline eosinophilic granuloma complex
nodular / linear area of raised, thickened skin, hair - loss
ulceration
pruritis
cause of feline eosinophilic granuloma complex
hypersensitivity reaction
treatment of feline eosinophilic granuloma complex
systemic gcc
megestrol acetate
causes of feline milary dermatitis
flea bite hypersensitivity
FAD
atopy
drug hypersensitivity
parasites
essential FA deficiency
clinical signs of feline milary dermatitis
mild popular reaction
pruritus
self trauma from lickinf
increased hairball vomitting
autoimmune disorders
pemphigus complex
pemphigus foliaceus
pemphigus vulgaris
pemphigus erythematous
pemphigus vegetans
bullous pemphigoid
pemphigus complex
vesiculobullous ulcerative disorders of the skin and mucosa
autoantibody directed against epidermal intercellular cement
pemphigus foliaceus
most common
clinical signs – vesiculobullous / exfoliative pustular dermatitis
hyperkeratosis of foot pads
diagnosis of pemphigus foliaceus
IF
pemphigus vulgaris
most severe
clinical signs - vesiculobullous lesions, ulcerative, erosive lesions, anorexia, depression, fever
discoid lupus erythematosus
nasal solar dermatitis / collie nose dermatitis
predisposed to discoid lupus erythematosus
collie
g. shepherd
shetland
sheepdog
huskey
how is discoid lupus erythematosus exacerabated
by sunlight
clinical signs of discoid lupus erythematosus
in dogs
erythema
alopecia
ulceration
loss of skin pigmentation
crsuting
scabbing
exudation
clinical signs of discoid lupus erythematosus
in cats
self excoriation
skin peeling
crusting
erythema
treatment of discoid lupus erythematosus
avoid sunlight
topical gcc
po pred
vit e
PABA containing suncream
predisposed to systemic lupus erythematosus
collie
shetland sheepdog
g. shepherd
autoantibodies against many tissues
how is systemic lupus erythematosus exacerbated
sunlight
clinical signs of systemic lupus erythematosus are differentiated into
non cutaneous
cutaneous
non cutaneous signs of systemic lupus erythematosus
polyarthritis
glomerulonephritis
lymphadenopathy
polymyositis
pyrexia
anaemia
pleuritis
pericarditis
cutaneous signs of systemic lupus erythematosus
mucocutaneous ulcers
seborrhea
footpad lesions
alopecia
pyoderma
diagnosis of systemic lupus erythematosus
IF of cutaneous lesions (major)
coombs positive (major)
thrombocytopaenia (major)
Fever, CNS signs, pleuritis (minor)
need 2 major and 1 minor
treatment of systemic lupus erythematosus
gcc
cytotoxic drugs
other causes of allergodermatitis
drug eruption
intestinal parasititic hypersensitivity
cold agglutinin disease
burns
frost bite
protein deficiency
essential FA deficiency
vitamin imbalances - A, biotin, nacin
zinc responsive dermatosis