Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

SAM Final > 33. Non-regenerative anaemias > Flashcards

33. Non-regenerative anaemias Flashcards

1
Q

Non regenerative anaemia

A

anaemias with a lack of regenerative response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Normal reticulocyte count

A

Dog: 60-80 x 10^9 cells/l
Cat: 15-42 x 10^9 cells/l

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Reticulocyte count during blood loss

A

x3 higer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Reticulocyte count during hemolysis

A

x7 higer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Polychromasia

A

when there is an increase of intensely stained rbcs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How long does it take rbcs to mature

A

4 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Causes of non regenerative anaemia

A

Drugs/ Toxins
Pathogens
BM Supression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Drugs causing non regenerative anaemia

A

chemo -
oestrogen
phenylbutazone
trimethoprim
phenobarbital
fenbendazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Pathogens that cause non regenerative anaemia

A

parvovirus
rickettsia
ehrlicia canis
fiv
histoplasma
leishmania
cryptococcus
feline panleukopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

non regenerative anaemia diseases

A

Pure red cell aplasia
Deficiency anaemias/ refractory anaemias
Anaemia of chronic disdease
Myelodysplastic syndromes
Acute lymphoblastic anaemia
Chronic lymphoblastic anaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Pure red cell aplasia

A

Immune mediated intravascular peracute haemolysis
NGIMHA
If it remains non regen for >5 days then the immune system targets erythroid precursor cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Predisposed to Pure red cell aplasia

A

Young/ middle aged
Neutered females

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Diagnosis of Pure red cell aplasia

A

Dysmyelopoesis
Haemorrhage
Fibrosis
Necrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Treatment of Pure red cell aplasia

A

Same as IMHA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Deficiency anaemias/ refractory anaemias

A

Anaemias not related to the bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

types of Deficiency anaemias/ refractory anaemias

A

Iron deficiency anaemia
Vitamin B12 deficiency
Chronic kidney disease

17
Q

Iron deficient anaemia

A

chronic blood loss
blood sucking parasites
chronic gi bleeding
chronic cystitis

18
Q

Vitamin B12 deficiency

A

Chronic git disease –> IBD
EPI
hereditary receptor defect - ebagle

19
Q

Chronic kidney diesease

A

eryhtropoietin loss
epo is porduced in the renal cortex

20
Q

Anaemia of chronic disease

A

lack of hormones
inflammation

21
Q

Lack of hormones

A

hypothyroidism
Addison’s

22
Q

Inflammation (Anaemia of chronic disdease)

A

cytokine release –> increased hepcidin release –> decreased ferritin –> decreased Fe availablilty

23
Q

Causes of inflammation

A

Chronic inflammatory disease (IBD)
Acute inflammatory disease (pyometra)
Chronic kidney disease
Neoplasia

24
Q

Myelodysplastic syndromes

A

a group of cancers
Immature RBCs fail to mature

25
Q

Clinical signs of Myelodysplastic syndromes

A

Weakness
Exercise intolerance
Fever
Haemorrhage

26
Q

Lab D of Myelodysplastic syndromes

A

Non regen
Panleukopenia
thrombocytopenia

27
Q

Diagnosis of Myelodysplastic syndromes

A

BM biopsy –> dyserythropoesis
increased myeloblasts

28
Q

Acute lymphoblastic anaemia

A

proliferation of immature lymphoblasts

29
Q

Predisposed to Acute lymphoblastic anaemia

A

middle/ old aged

30
Q

Clinical signs of Acute lymphoblastic anaemia

A

Lethargy
Weight loss
intermittent fever
hepatosplenomegaly
abdo pain

31
Q

Lab D of Acute lymphoblastic anaemia

A

anaemia
leukopenia
no lymphoblasts in peripheral blood

32
Q

Diagnosis of Acute lymphoblastic anaemia

A

BM biopsy

33
Q

Differential of Acute lymphoblastic anaemia

A

Lymphoma stage V

34
Q

Chronic lymphoblastic anaemia

A

proliferation of mature lymphocytes

35
Q

Predisposed to Chronic lymphoblastic anaemia

A

old >young

36
Q

Clinical signs of Chronic lymphoblastic anaemia

A

Hepatosplenomegaly
intermittent lameness
mild lymphadenomegaly
fever
pu/pd
haemorrhages

37
Q

Lab D of Chronic lymphoblastic anaemia

A

Normocytic normochromic non regenerative anaemia
Lymhphocytosis
Neutropenia

38
Q

Treatment of Chronic lymphoblastic anaemia

A

prednisolone & chlorambucil

39
Q

Treatment of non regenerative anaemia

A

Treat underlying cause
Blood transfusion - packed RBCs

SAM Final (48 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions