WBC, LN, Spleen

Question 1

cut off value for clinically significant neutropenia

Answer 1

<500/mm3

considered agranulocytosis

Question 2

most common cause of agranulocytosis

Answer 2

drug toxicity

Question 3

___ syndrome is associated with inadequate of ineffective granulopoiesis

Answer 3

kostmann syndrome

Question 4

___ syndrome of ineffective hematopoeisis. abnormal cells die before they can go out of the marrow resulting to low peripheral blood counts and compensatory hypercellular marrow

Answer 4

myelodysplastic syndrome

Question 5

___ center is the area of B-cell activation

Answer 5

germinal center

Question 6

___ zone contains small, naive B cells in LN

Answer 6

mantle zone

Question 7

pattern of hyperplasia seen in acute viral infections; mottled appearance

Answer 7

paracortical hyperplasia

Question 8

[diagnosis]

younger, primitive cells, aggressive clinical course, amenable to treatment

Answer 8

Acute leukemia

Question 9

[diagnosis]

older, mature looking cells, indolent clinical course, subtle symptoms, resistant to treatment

Answer 9

chronic leukemia

Question 10

sanctuary sites of Bcell ALL and T cell ALL

Answer 10

testis

Question 11

this refers to absence of blasts in peripheral blood; >100,000/mm3

Answer 11

aleukemic leukemia

Question 12

t(15;17)

Answer 12

APML

Question 13

t(12;21)

Answer 13

B-CELL ALL

Question 14

NOTCH-1 mutation

Answer 14

T-CELL ALL

Question 15

[diagnosis]

needle-like azurophilic granules

Answer 15

APML

auer rods

Question 16

___ cells when there are numerous auer rods. seen in APML. Associated with DIC

Answer 16

faggot cells

Question 17

[diagnosis]

constitutional symptoms, hepatosplenomegaly, lymphadenopathy, hypogammaglobinemia, >5,000/mm3 PBS, small lymphocytes with smudge cells

Answer 17

CLL

Question 18

[diagnosis]

constitutional symptoms, hepatosplenomegaly, lymphadenopathy, hypogammaglobinemia, <5,000/mm3 PBS, small lymphocytes with smudge cells

Answer 18

SLL

Question 19

Chronic lymphomas that can undergo Richter Syndrome

Answer 19

CLL, SLL

Question 20

progression of CLL to DLBCL is called

Answer 20

richter syndrome

Question 21

t(9;22)

Answer 21

CML

Question 22

[diagnosis]

WBC >100,000/ mm3
thrombocytosis
Blast <10% in PBS

Answer 22

CML

Question 23

[diagnosis of CML phase]

1. Increasing WBC unresponsive to therapy
2. Basophils >20%
3. Thrombocytes <100,000 unrelated to therapy OR
4. > 1,000,000 unresponsive to therapy
5. increasing splenomegaly

Answer 23

Accelerated phase

Question 24

____ (low/high) leukocyte alkaline phosphatase level in CML

Answer 24

low

Question 25

receptor used by drugs in treating CML

Answer 25

Tyrosine Kinase DOC: imatinib

Question 26

[diagnosis] LN: large, multiple nuclei or single with multiple lobes, each with nucleolous

Answer 26

Hodgkin lymphoma

Question 27

[subtype of HL] Reactive T-cells with fibrous bands forming nodules, not associated with EBV

Answer 27

nodular sclerosis

Question 28

[subtype of HL] mixed leukocytic infiltrate without fibrous nodules, 70% associated with EBC

Answer 28

mixed cellularuty

Question 29

[subtype of HL] rich reactive T-cell infiltrate, 40% associated with EBV

Answer 29

lymphocyte rich

Question 30

[subtype of HL] rare reactive lymphocyte, CD15 + and CD 30 +; mostly associated with EBV

Answer 30

lymphocyte depleted

Question 31

[subtype of HL] reactive B cells, popcorn reed steinberg cells, not associated with EBV CD15 (-) CD30 (-) CD20 (+)

Answer 31

Lymphocyte predominant

Question 32

staging system used in hodgkin lymphoma

Answer 32

ann arbor classification

Question 33

most common indolent lymphoma of adults

Answer 33

follicular lymphoma

Question 34

[diagnosis] painless, generalized lymphadenopathy, BMA: paratrabecular lymphoid aggregates, can undergo richter syndrome transform to DLBCL or Burkitt lymphoma

Answer 34

Follicular lymphoma

Question 35

[diagnosis] LN involved: single, axial group of nodes (cervical, mediastinal, para-aortic, contiguous spread

Answer 35

Hodgkin lymphoma

Question 36

[diagnosis] LN involvement: multiple, peripheral LN, non-contiguous spread, has extranodal presentation, mesenteric and waldeyer ring are commonly involved

Answer 36

non-hodgkin lymphoma

Question 37

most common lymphoma of adults

Answer 37

Diffuse large B-cell lymphoma

Question 38

[diagnosis] approx 60/M rapidly enlarging mass at nodal or extranodal site, histologically, diffuse pattern of growth; large cell with highly anaplastic appearance

Answer 38

DLBCL

Question 39

Immunostains used in DLBCL

Answer 39

CD45, Cytokeratin, vimentin

Question 40

fastest growing human tumor

Answer 40

Burkitt lymphoma

Question 41

[diagnosis] children/young adults, mandibular mass, 100% latent infection with EBV Histologically: diffuse infiltration of medium-sized anaplastic lymphocytes that phagocytose apoptotic lymphocytes

Answer 41

Endemic burkitt

Question 42

[diagnosis] children/young adults, ileocecum, peritoneal mass, 15-20% latent infection with EBV Histologically: diffuse infiltration of medium-sized anaplastic lymphocytes that phagocytose apoptotic lymphocytes

Answer 42

Sporadic burkitt

Question 43

t(8;14) mutation

Answer 43

burkitt lymphoma

Question 44

[diagnosis, type of NHL] type of lymphoma that can arise in salivary glands (sjogren syndrome), thyroid gland (hashimoto thyroiditis), stomach (H. pylori)

Answer 44

marginal zone lymphoma

Question 45

[diagnosis] infiltration of epidermis and upper dermis T cells with cerebriform nuclei

Answer 45

mycosis fungoides/Cutaneous T cell lymphoma

Question 46

____ syndrome associated with mycosis fungoides characterized as generalized exfloative erythroderma and leukemia T-cells with cerebriform nuclei

Answer 46

Sezary Syndrome

Question 47

[diagnosis] 65-75 years old, PAS(+) cytoplasmic (russel bodies) or nuclear inclusion (dutcher bodies) containing Ig

Answer 47

Multiple myeloma

Question 48

[diagnosis] punched out bone lesions, bence-jone proteinuria, hypercalcemia

Answer 48

Multiple myeloma

Question 49

[type of MDS] Prussian blue (+) iron-laden mitochondria in erythroblast, megaloblastoid maturation, nuclear budding, abnormalities, mishapen polypoid nuclei

Answer 49

erythroid MDS

Question 50

[type of MDS] | presence of PMNs with only 2 lobes

Answer 50

granulocytic MDS pseudo pelger huet cell

Question 51

[diagnosis] pseudo Pelger Huet Cell

Answer 51

Granulocytic MDS

Question 52

[type of MDS] megakaryocyte with multiple separated nuclei

Answer 52

megakaryocytic MDS

Question 53

[diagnosis] pawn ball megakaryocyte

Answer 53

megakaryocytic MDS

Question 54

[diagnosis] JAK2 mutation plethoric, thrombosis, infarcts, hemorrahge, hyperuricemia, gout, throbbing and burning of hands and feet due to thrombotic occlusion by platelet aggregates

Answer 54

PV

Question 55

[diagnosis] Thrombosis, infarcts, hemorrhage, escape of erythroid and granulocytic precursos into circulation and sites of extramedullary hematopoiesis

Answer 55

Essential Thrombocytopenia

Question 56

[diagnosis] extensive deposition of collagen in marrow by non-neoplastic fibroblasts; WBC and platelet predominance, pronounced hepatosplenomegaly, hyperuricemia/gout, presence of dacrocytes, fibrotic marrow converted into bone, osteo sclerosis

Answer 56

Primary myelofibrosis

Question 57

[diagnosis] proliferative disorder of dendritic cells in skin, presence of birbeck granules, presence of racket shaped granules

Answer 57

langerhands histiocytosis

Question 58

[diagnosis] birbeck granules, pentalaminar racket-shaped granules

Answer 58

langerhans histiocytosis