Diseases of the Immune System

Question 1

[type of hypersensitivity reactions]

eosinophils, IL5 from TH2, Antigen binds to IgE on basophils and mast cells
edema, smoothmuscle contraction, mucus production

Answer 1

Type 1

Question 2

[type of hypersensitivity reaction]

Antibodies activate C3a and C5a; functional derangement without evidence of cell or tissue injury

Answer 2

Type II

Question 3

[type of hypersensitivity]

deposition of Ag-Ab complex, inflammation, necrotizing vasculitis, arthus reaction (local)

Answer 3

Type III

Question 4

Granzymes found in CD8 T cell mediate direct killing of antigen by

Answer 4

cleaving and activating caspases

Question 5

Best screening test for SLE

Answer 5

ANA

Question 6

Correlates with disease activity of SLE

Answer 6

anti-dsDNA

Question 7

Specific for SLE

Answer 7

anti-smith, anti-dsDNA

Question 8

[class of lupus nephritis]

Normal LM, ICs in mesangium

Answer 8

minimal change disease (Class I)

Question 9

[class of lupus nephritis]

Messangial cell proliferation, granular mesangial Ig and complement WITHOUT involvement of glomerular capillaries

Answer 9

Mesangial proliferative (Class II)

Question 10

<50% of glomeruli involved, wire-loop appearance, subendothelial IC deposits

Answer 10

Focal (Class III)

Question 11

> /50% of glomeruli involved, wire-loop appearance, subendothelial IC deposits

Answer 11

Diffuse (Class IV)

Question 12

diffuse capillary thickening, subepithelial deposits

Answer 12

Membranous (Class V)

Question 13

Dry eyes, dry mouth, destruction of lacrimal and salivary glands

Answer 13

Sjogren Syndrome

Question 14

Chronic Inflammation, damage to small vessels, rubber hose inflexibility of esophagus, sclerotic atrophy of the skin, thinning of the epidermis, intimal thickening of interlobular arteries

Answer 14

Systemic Sclerosis/Scleroderma

Question 15

Components of CREST syndrome

Answer 15

Calcinosis
Reynaud Phenomenon
Esophageal dysmotility
Sclerodactyly
Telangectasia

Question 16

Autoantibodies in diffuse scleroderma

Answer 16

Anti-DNA topoisomerase I

Question 17

[Allorecognition pathway]

Donor Ags presented by recepient APCs to recipient T cells

Answer 17

Indirect pathway

Question 18

Occulocutaneous albinism, immunodeficiency, mild bleeding tendency

Answer 18

Chediak-Higashi syndrome

o,paored phagolysosome

Question 19

NADPH oxidase deficiency

Answer 19

CGD

Question 20

Oral candidiasis, extensive diaper rash, failure to thrive, morbiliform rash due to GVHD; due to adenosine deaminase deficieny

Answer 20

SCID

Question 21

Oral candidiasis, extensive diaper rash, failure to thrive, morbiliform rash due to GVHD; due to adenosine deaminase deficieny

Answer 21

SCID

Question 22

At 5 to 6 months of age, noted infection H. influenzae, S. pneumoniae, S. aureus, enterovirus, giardia lamblia

Answer 22

Bruton aggamoglobinemia

Question 23

Thrombocytopenia, Infections/Immunodeficiency, Eczema

Low IgM, normal IgG, Increased IgA, Increased IgE

Answer 23

Wiskott-Aldrich Syndrome

Question 24

HIV initially infects ___ cells

Answer 24

dendritic

Question 25

[HIV life cycle]

gp120 binds to ____ during attachment

Answer 25

CXCR4 and CCR5

Question 26

[HIV life cycle]

____ is the fusion protein used to integrate itself into host cel

Answer 26

gp41

Question 27

apple green bifringence under polarized light

in the spleen, tapioca-like granules (sago spleen); coalesce of deposits: map-like areas (lardaceous spleen)

Answer 27

amyloidosis