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Pathology > Skin > Flashcards

Skin Flashcards

1
Q

Dysplastic nevus is a marker of increased risk of ___

A

melanoma

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2
Q

[diagnosis: melanoma]

basal layer of epidermis involved, no atypia or mitosis

A

Lentigo

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3
Q

[diagnosis: melanoma]

epidermis and dermis involved; atypical cells present in epidermis

atypia and mitosis present

A

dysplastic nevus

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4
Q

[diagnosis: melanoma]

epidermis and superficial dermis involved; atypia present, capable of radial growth; not capable of vertical growth

A

Early melanoma

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5
Q

[diagnosis: melanoma]

epidermis, dermis and other structure involved

atypia present, radial growth capable, vertical growth capable

A

advanced melanoma

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6
Q

melanocytes are ___ cells

melanocyte marker: HMB-45

A

neural crest cell-derived

marker: S100

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7
Q

___ growth in melanoma has a metastatic potential

A

vertical growth

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8
Q

tumor depth in melanoma is the distance between

A

superficial granular cell layer and deepest intradermal tumor involvement

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9
Q

[diagnose]

small pore-like ostia impacted with keratin

small, keratin-filled cyst, exuberant keratin production, basaloid cells, invaginations of keratin

A

seborrheic keratosis

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10
Q

___ sign

rapid increase in seborrheic keratitis. Paraneoplastic syndrome of GI malignancies

A

Leser-Trelat sign

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11
Q

[diagnose]

thickened, hyperpigmented skin, velvel like texture in flexural areas

Histo: basal cell hyperpigmentation WITHOUT melanocytic hyperplasia

A

acanthosis nigricans

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12
Q

[diagnose]

atypical dyskeratotic cells in basal epidermis with intercellular bridges, basophilic degenerative changes in elastic fiber, hyperkeratosis

premalignant lesion to squamous cell CA

A

Actinic Keratosis

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13
Q

most common invasive cancer in humans

A

basal cell CA

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14
Q

second most common tumor arising from sun-exposed areas in older people

A

squamous cell CA

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15
Q

[diagnose]

plaques to nodules with ulceration

Histo: full thickness of epidermis with dermal invation, keratin pearl formation, dyskeratotic cells

A

Squamous cell CA

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16
Q

[diagnose] pearly papules with telangectasia; (rodent ulder)

nests of basaloid with peripheral palisading; stromal retraction

A

basal cell CA

lower metastatic potential

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17
Q

___ syndrome

Multiple BCCA before age 20
medulloblastoma
ovarian fibroma
odontogenic keratocyts
pitls on palms and soles
developmental anomalis
A

Gorlin Syndrome

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18
Q

[diagnose: urticaria]

increase in microvascular permeability of the deeper dermis and subcutaneous fat

A

urticaria

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19
Q

[diagnose]

superficial dermal edema
sparse superficial perivenular mononuclear infiltrate

Mast cell and IgE mediated

A

urticaria

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20
Q

[diagnose: acute eczematous dermatitis]

superficial dermal perivascular mononuclear infiltrate

A

contact dermatitis

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21
Q

[diagnose: acute eczematous dermatitis]

superficial and deep dermal perivascular lymphocytic infiltrate with eosinophils

A

Internal

22
Q

[diagnose]

hyperkeratosis
acanthosis
spongios

A

acute eczematous dermatitis

23
Q

Dermal edema can seep into this skin layer causing intraepidermal vesicles

A

stratum spinosus

24
Q

[diagnose]

patient took antimalarials

red macule or papule with a pale, vesicular, or eroded center; superficial perivascular, lymphocytic infiltrate; dermal edema

A

Erythema multiforme

25
Q

[spectrum of erythema multiforme]

> 30% BSA, split formed by bliseter at dermoepidermal junction

A

TEN

26
Q

accumulation of these cells in the epidermis leads to cytokine and growth factor over production leading to epidermal cell proliferation

A

CD4 TH1
TH17
CD8

27
Q

[diagnose]

salmon-colored plaques covered by loosely adherent silvery-white scales

A

psoriasis

28
Q

[diagnose]

test tubes in a rack appearance, munro microabscesses, spongiform pustules of Kogoj

A

psoriasis

29
Q

[psoriasis]
____
neutrophils in spongiotic foci of the superficial epidermis

A

Spongiform pustules of Kojog

30
Q

[psoriasis]

neutrophils within the parakeratotic stratum corneum

A

munro microabcesses

31
Q

test tubes in a rack appearance in psoriasis is due to elongation of?

A

rete ridges

32
Q

[diagnose]

follicular lipping: mounds of parakeratosis containing PMNs and sebum at the ostia of hair follicle

A

seborrheic dermatitis

33
Q

[lichen planus]

white dots/lines on papules

A

wickham striae

34
Q

[diagnose]

pruritic, purple, polygonal, planar papules and plaques

Histo: epiderma hyperplasia, hyperkeratosism hypergranulosis, interface dermatosis

Sawtooth appearance of DEJ

civatte or colloid bodies

A

lichen planus

35
Q

keratinocytes in the epidermis are connected to each other by ___

A

desmosomes

36
Q

basal cells in the skin are anchored to the basement membrane by ___

A

hemidesmosomes

37
Q

___ is the target structure in pemphigus vulgaris resulting acantholysis

A

desmoglein

38
Q

[diagnose]

suprabasilar blister, lacelike fluorescence patter, Ig G deposits in squamous region, acantholysis, positive nikolsky sign

A

Pemphigus vulgaris

39
Q

this is the targe structure in bullous pemphigoid antigen

A

hemidesmosome

40
Q

[diagnose]

IgG deposition in the epidermal basement membrane zone, subepidermal blisters linear patter, no acanthiolysis, negative nikolsky sign

A

bullous pemphigoid

41
Q

target of antigen in dermatitis herpetiformis

A

reticulin

42
Q

[diagnose]

subepidermal blister, IgA deposition in the epidermal basement membrane, granular pattern with fibrin and PMNs at tips of dermal papillae

A

dermatitis herpetiformis

43
Q

Paraneoplastic pemphigus is associated with

A

NHL

44
Q

dematitis herpetiformis is associated with

A

celiac disease

45
Q

[diagnosis]

defect in keratin, laminin and BPAGs, and type VII collagen

A

epidermolysis bullosa

46
Q

[diagnosis]

Inherited defect in heme metabolism; blocks late in heme synthesis lead to sun-induced skin damage

A

porphyria

47
Q

[diagnose]

histologic hallmark is comedogenesis

A

acne vulgaris

48
Q

[diagnose, identify the etiologic agent]

gray-white to tan, flat to convex papules, with pebbly surface

Histo: papillimatous epidermal hyperplasia; koilocytic change

A

HPV

this is a case of Verucae

49
Q

[diagnose, identify the etiologic agent]

pruritic, pink to skin-colored papules with central umbilication

Histo: large, ellipsoid, homogenous, cytoplasmic inclusions in stratum granulosum and corneum

A

poxvirus

Molluscum contangiosum

50
Q

[diagnose, identify the etiologic agent]

honey-colored crust, bullae

Histo: accumulation of neutrophils beneath the stratum corneum

A

GABHS (contangiosa)
S. aureus (bullosa)

Impetigo

Pathology (36 decks)

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