Red Blood Cell and Bleeding Disorders

Question 1

ratio of the volume of erythrocytes to that of whole blood

Answer 1

hematocrit

Question 2

average volume of red cells

Answer 2

MCV

Question 3

weight of Hgb of the average red cell

Answer 3

MCH

Question 4

Average concentration of hemoglobin in a given volume of packed red cell

Answer 4

MCHC

Question 5

Reflects variability in red cell and shape

Answer 5

RDW

Question 6

[red cell index]

___ = Hgb/3

Answer 6

Hct

Question 7

[red cell index]

____ = RBC x 3

Answer 7

Hgb

Question 8

[red cell index]

___ = Hct/RBC

Answer 8

MCV

macrocytic, microcytic, normocytic

Question 9

[red cell index]

_____ = Hgb/RBC

Answer 9

MCH

hypochromic, normchromic

Question 10

[red cell index]

____ = (Hgb/Hct) x 100

Answer 10

MCHC

Question 11

[diagnosis]

increased MCHC, RBC is round, without central pallor

intrinsic type of hemolysis, extravascular site of hemolysis

Answer 11

Hereditary spherocytosis

Question 12

[diagnosis]
Heins bodies, Bite Cells, Protective against malaria

intrinsic type of hemolysis, intravascular and extravascular site of hemolysis

Answer 12

G6PD deficiency

Question 13

[diagnosis]
presence of codocytes (dehydrated RBCs), drepanocytes, protective against malaria, extramedullary hematopoeisis

intrinsic type of hemolysis, extravascular site of hemolysis

Answer 13

Sickle cell anemia

Question 14

[diagnosis]

E6V mutation; RBC changes shape in low pH and low oxygen tension

Answer 14

Sickle cell anemia

Question 15

Hydroxyurea is used in treating sickle cell anemia. This increasesthe ____

Answer 15

HbF

Question 16

[diagnosis]

symptomatic infants starting 5-6 months of age, acute splenomegaly, painful vaso-occlusive crisis, causes autosplenectomy

Answer 16

sickle cell anemia

Question 17

[diagnosis]

infants become symptomatic at 6-9 months of age, crew-cut appearance

microcytic, hypochromic anemia, intrinsic type, extravascular hemolysis

Answer 17

beta thalassemia

Question 18

[diagnosis]

deficiency in complement regulatory proteins CD55, CD59, C8 binding protein

increased complement mediated lysis (C5-9)

less blood pH at night, increases complement activity

Answer 18

Paroxysmal Nocturnal Hemoglobinuria

Question 19

most common immunohemolytic anema

Answer 19

warm agglutinin

Question 20

[type of immunohemolytic anemia]

IgG

Associated with SLE nad drugs

Answer 20

warm agglutinin

Question 21

[type of immunohemolytic anemias]

IgM mediated
associated with mycoplasmal infections and infectious mononucleosis

prefers fingers, toes, aears

Answer 21

Cold agglutinin disease

Question 22

[type of agglutinin]

low RBC, increased MCV, increased MCHC

PBS: red cell agglutination

Answer 22

cold agglutinins

Question 23

[hypoproliferative anemia]

impaired nuclear maturation with normal cytoplasmic maturation (nuclear-cytoplasmic asynchrony); abnormally large erythroid precursors and red cells; megakaryocyte is large with bizarre, multilobate nuclei

Answer 23

megaloblastic anemia

Question 24

[diagnosis]

anisocytosis, poikilocytosis, giant metamyelocytesa nd band forms (>/ 5 lobes)

megakaryocyte: large, with bizarre, multilobate

Answer 24

megaloblastic anemia

Question 25

vitamin deficiency associated with neurologic manifestations (degeneration of posterolateral cord tracts)

Answer 25

Vitamin B12

Question 26

[type of anemia] microcytic, hypochromic, increased RDW low serum Fe, low ferritin, increased TIBC

Answer 26

IDA

Question 27

[type of anemia] | low serum iron, high ferritin, low transferrin

Answer 27

Anemia of chronic disease

Question 28

[diagnosis] Normocytic, normochromic BMA: hypocellular, dry tap

Answer 28

Aplastic anemia

Question 29

[diagnosis] normocytic, normochromic BMA: virtually absent erythroblasts in marrow, normal granulo- and thrombopoietic elements

Answer 29

pure red cell aplasia

Question 30

virus that preferentially infect erythroid precurosrs

Answer 30

parvovirus

Question 31

[diagnosis] space occupying lesion that replace normal marrow elements; tear-drop shaped cells

Answer 31

myelopthisic anemia

Question 32

[diagnosis] abnormally high red cell county with increase in hemoglobin;

Answer 32

polycythemia vera

Question 33

deranged bleeding ime means there is a defect in platelet _____

Answer 33

function

Question 34

[diagnosis] usually seen in adults 40y/o, associated with SLE, CLL, HIV; antibodies against gp IIb-IIIa, gbIb-IX BMA: increased megakaroyocytes PBS: large platelets Spleen congestion, follicular hyperplasia Treated with glucocorticoids

Answer 34

Chronic ITP

Question 35

[diagnosis] usually seen in children associated with post-viral illness; antibodies against gp IIb-IIIa, gbIb-IX BMA: increased megakaroyocytes PBS: large platelets Spleen congestion, follicular hyperplasia self limited`

Answer 35

acute itp

Question 36

[diagnosis] defect in platelet adhesion due to deficiency in gpIb-IX

Answer 36

bernard-soulier disease

Question 37

[diagnosis] defect in platelet aggregation due to deficiency in gpIIb-IIIa

Answer 37

glanzman thrombastenia

Question 38

most common inherited bleeding disorder

Answer 38

von willebrand disease

Question 39

[diagnosis] platelet count: normal bleeding time: impaired

Answer 39

von willebrand

Question 40

[diagnosis] platelet count: normal bleeding time: normal

Answer 40

hemophilia

Question 41

most common hereditary syndrome with life threatening bleeding

Answer 41

hemophilia

Question 42

[diagnosis] 1. microangiopathic hemolytic anemia 2. Thrombocytopenia 3. Renal failure

Answer 42

Hemolytic Uremic Syndrome normal ADAMTS13 level

Question 43

[diagnosis] 1. microangiopathic hemolytic anemia 2. Thrombocytopenia 3. Renal failure 4. Fever 5. Neurologic manifestation

Answer 43

Thrombotic Thrombocytopenic Purpura

Question 44

[diagnosis] ADAMTS13 is decreased

Answer 44

TTP

Question 45

this is a metalloproteinase of vWF that is normal in HUS

Answer 45

ADAMTS13

Question 46

___ syndrome wherein a thrombi lodged to a gian hemangioma (DIC-related)

Answer 46

Kasabach-Merritt Syndrome)

Question 47

[diagnosis] low PC, prolonged bleeding time, prolonged PT, prolonged aPTT

Answer 47

DIC

Question 48

[diagnosis, bleeding disorders] PC: normal Bleeding time: normal PT: normal PTT: normal

Answer 48

Ehler-Danlos

Question 49

[diagnosis, bleeding disorders] PC: low Bleeding time: prolonged PT: normal PTT: normal

Answer 49

ITP or TTP

Question 50

[diagnosis, bleeding disorders] PC: low Bleeding time: prolonged PT: normal PTT: normal

Answer 50

Bernard soulier

Question 51

[diagnosis, bleeding disorders] PC: normal Bleeding time: prolonged PT: normal PTT: normal

Answer 51

glanzmann thrombastenia

Question 52

[diagnosis, bleeding disorders] PC: normal Bleeding time: prolonged PT: normal PTT: prolonged

Answer 52

vWF disease

Question 53

[diagnosis, bleeding disorders] PC: normal Bleeding time: normal PT: normal PTT: prolonged

Answer 53

hemophilia

Question 54

[diagnosis, bleeding disorders] PC: normal Bleeding time: normal PT: prolonged PTT: prolonged

Answer 54

vitamin K deficiency

Question 55

[diagnosis, bleeding disorders] PC: low Bleeding time: prolonged PT: prolonged PTT: prolonged

Answer 55

DIC

Question 56

[type of transfusion reaction] presence of preformed IgM to donor red cell antigen

Answer 56

Acute hemolytic transfusion reactions

Question 57

[type of transfusion reaction] IgG to red cell antigen the patient was previously sensitized to

Answer 57

Delayed

Question 58

[type of transfusion reactions] | Activation of PMNs in lung vasculature

Answer 58

TRALI