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Pathology > Female Genital Tract Pathology > Flashcards

Female Genital Tract Pathology Flashcards

1
Q

[diagnosis]

plasma cells in endometrial stroma

A

chronic endometritis

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2
Q

[diagnosis]

lymphocytes or plasma cells in cervical stroma

A

chronic cervicitis

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3
Q

[diagnosis]

pelvic pain, adnexal tenderness, fever, vaginal discharge

A

PID

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4
Q

[diagnosis]

gross: leukoplakia of the vulva

thinning of the epidermis, basal cell degeneration, hyperkeratosis, sclerotic changes of superficial dermis, dermal lymphocytic infiltrate

A

lichen slerosus

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5
Q

[diagnosis]

gross: leukoplakia of the vulva

acanthosis, mitosis, hyperkeratosis, lymphocytic infiltrates

A

squamous hyperplasia

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6
Q

[diagnosis]

failure of mullerian duct fusion, accompanied by uterine didelphys

A

septate vagina

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7
Q

vaginal anomaly associated with DES exposure

A

septate vagina

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8
Q

[diagnosis]

___ cyst

remnant of wolffian or mesonephric duct

A

gartner duct cyst

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9
Q

most common primary vulvar CA

A

squamois cell CA

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10
Q

[diagnosis]

patient 4 years old, gross presence of grape-like clusters

A

sarcoma botryoides

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11
Q

___ term for small, with oval nuclei and tennis racket like appearance with or without striations in sarcoma botryoides

A

embryonal rhabdomyoblast

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12
Q

[diagnosis]

fibromyxoid stroma, lined by endocervical type epithelium, usually with inflammation

A

endocervical polyp

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13
Q

[HPV]

Infects: _____ (mature/immature)

Replicates in: ______ (mature/immature)

A

Infects immature cells

replicates in mature cells

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14
Q

[HPV]

E___ inactivates Rb leading to cell proliferation

A

E7

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15
Q

[HPV]

E___ inactivates p53 leading to cellular immortality

A

E6

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16
Q

[diagnosis: CIN]

nuclear atypia with cytoplasmic “halos”, confined to lower third of epithelium

A

LSIL

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17
Q

[diagnosis: CIN]

nuclear atypia with cytoplasmic “halos”, expansion to upper two-thirds of epithelium

A

HSIL

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18
Q

[diagnosis]

CIN + invasion beyond the basement membrane

A

cervical CA

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19
Q

[diagnosis]

infertility, dysmenorrhea, chronic pelvic pain

Gross: subserosal red-blue to yellow brown nodules on sites of involvement, ovaries may be converted to cyst

Histology: endometrial glands and stroma

Cyst lining: hemosiderin-laden macrophages in old hemorrhage, fibrosis

A

endometriosis

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20
Q

[diagnosis]

chocolate cyst

A

endometriosis

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21
Q

[diagnosis]

menometorrhagia, colicky dysmenorrhea, dyspareunia, premenstrual pelvic pain

gross: symmetrically enlarged corpus, with multiple blood lakes within the myometrium
histo: (+) endometrial stroma, with or without glands, within the myometrium, separated from the decidual basalis by 2 to 3 mm

A

adenomyosis

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22
Q

[diagnosis]

due to retrograde menstruation

A

endometriosis

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23
Q

[diagnosis]

exophytic mass that project into endometrial cavity, clinically silent AUB, seen in patient on tamoxifen

A

endometrial polyp

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24
Q

[diagnosis]

precursor to endometrial CA type I, important cause of AUB

A

endometrial hyperplasia

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25
Q

most common malignancy of the female genital tract

A

endometrial carcinoma

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26
Q

[diagnosis]

postmenopausal bleeding, increased exposure to estrogen

A

endometrial CA

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27
Q

inactivation of this tumor suppressor gene can lead to atypical hyperplasia leading to endometrial CA

A

PTEN

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28
Q

precursor lesion to Type II endometrial CA

A

serous endometrial intraepithelial CA

29
Q

a tumor suppressor gene that is associated with endomterial CA microsatellite instability

A

KRAS

30
Q

[diagnosis: endometrial CA type]

localized polypoid tumor, has three grades, glandular and solid; mild to moderate atypia

A

type I endometriod

31
Q

[diagnosis: endometrial CA type]

atrophic uterus with large bulky, infiltrative mass

presence of papillary fronds, marked atypia

A

Type II serous

32
Q

most common tumor in women

A

leiomyoma

33
Q

[diagnosis]

not encapsulated, well circumscribed, grayish-white tumor, intramural

absent necrosis, scarce to low mitotic figure, absent to mild atypia

A

leiomyoma

34
Q

[diagnosis]

bulky, fleshy mass invading the uterine wall or polypoid mass projecting to the uterine lumen

atypia is present, necrosis is present

A

leiomyosarcoma

35
Q

[diagnosis]

uterine mass wherein the glands are benign, stroma is malignant

A

adenosarcoma

36
Q

[diagnosis]

uterine mass wherein the glands are malignant, stroma are malignant

A

malignant mixed mullerian tumor

37
Q

fallopian tube epithelium that is related to high-grade serous carcinoma

A

serous tubal intraepithelial carcinoma

38
Q

[diagnosis: ovarian cyst]

ovarian cyst 2cm

A

cystic follicle

39
Q

[diagnosis: ovarian cyst]

ovarian cyst > 2cm

A

follicle cyst

40
Q

rupture of this ovarian cyst can lead to peritoneal reaction

A

luteal cyst

41
Q

Stein-Leventhal Syndrome is also called

A

PCOS

42
Q

most common ovarian tumors

A

mullerian epithelium (germ cell, sex cord-stromal, metastatic)

43
Q

most common surface epithelial tumors of the ovary

A

serous

44
Q

tumor marker for ovarian CA used to monitor recurrence and progression

A

CA 125

45
Q

presence of _____ in surface epithelial tumors distinguish borderline from benign tumors

A

stromal invasion

46
Q

presence of ____ in surface epithelial tumors distinguishes borderline tumors from benign tumors

A

atypia and complex architecture

47
Q

[diagnosis: type of serous ovarian tumor]

mutation of TP53, KRAS, BRAF

Mucinous, low grade

A

Type I

48
Q

[diagnosis: type of serous ovarian tumor]

mutation of TP53, BRCA, PIK3CA

Serous, high grade

A

Type II

49
Q

[diagnosis: ovarian tumor]

non-ciliated, tall columnar, usually unilateral, can produce large mass

associated with pseudomyxoma peritoni

A

mucinous tumor

50
Q

most common site of mucinous tumor in pseudmyxoma peritoni

A

appendix

51
Q

most common germ cell tumor

A

mature cystic teratoma

52
Q

[diagnosis]

presence of tubular glands resembling benign or malignant endometrium; squamous differentiation

A

endometriod tumors

53
Q

most common MALIGNANT germ cell tumor

A

dysgerminoma

54
Q

[diagnosis: germ cell tumor]

nest of large, vesicular cells with clear cytoplasm, centrally located nuclei with lymphocytic infiltration

tumor marker: KIT

A

dysgerminoma

55
Q

[diagnosis: germ cell tumor]

central blood vessels enveloped by tumor cells within a space lined by tumor cells (+) hyaline bodies

Tumor marker: AFP

A

Yolk sac tumor/endodermal sinus tumor

56
Q

[diagnosis: germ cell tumor]

schiller-duval bodies

A

Yolk sac tumor/endodermal sinus tumor

57
Q

[diagnosis: germ cell tumor]

tumor marker: HCG

A

ovarian choriocarcinoma

58
Q

[diagnosis: sex-cord stromal tumors]

hyperestrenism,

presence of call exner bodies

Tumor marker: estrogen, inhibin

A

granulosa cell tumor

59
Q

[diagnosis: sex-cord stromal tumors]

defemination, virilization

tumor marker: androgen

A

Sertoli-leydig cell tumor

60
Q

[diagnosis: sex-cord stromal tumors]

mass effect, associated with Meigs syndrome

fibroblast-like cells or plump spindle cells

tumor marker: none

A

Thecoma/Fibroma

61
Q

[diagnosis]

Hydrothorax
ascites
ovarian tumor

A

Meigs Syndrome

62
Q

[diagnosis: sex-cord stromal tumors]

small, cuboidal to polygona cells in sheets, cords, may recapitulate with central acidophilic material

A

granulosa cell tumor

63
Q

[diagnosis]

cystic swelling of the chorionic villi with trophoblastic invasion

A

Hydatidiform mole

64
Q

[diagnosis: H. mole]

46XX, most common

A

complete mole

65
Q

[diagnosis: H. mole]

69XXX or 69 XXY

A

partial mole

66
Q

[diagnosis: H. mole]

missed abortion, small for dates uterine size, initial hCg <100,000

embyo-fetus, Amnion, fetal erythrocyte present, focal villous edema, mild trophoblastic atypia

A

partial mole

67
Q

[diagnosis: H. mole]

molar gestation, large for dates uterine size, initial hCg >100,000, absent fetal parts, absent amnion

widespread villous edema, marked trophoblastic proliferation and atypia

A

complete mole

68
Q

[diagnosis]

proliferation of syncitiotrophoblast and cytotrophoblast without villi formation

rapidly invasive, metastasizing but responsive to chemo

A

choriocarcinoma

69
Q

[diagnosis]

proliferation of syncitiotrophoblast and cytotrophoblast WITH villi formation

rapidly invasive, metastasizing but responsive to chemo

A

invasive mole

Pathology (36 decks)

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