Neoplasia

Question 1

-oma usually connotes a benign tumor except

Answer 1

seminoma
lymphoma
melanoma
hepatoma

Question 2

___ is a tumor-like condition where an ectopic tissue is cytologically and architecturally normal

Answer 2

Choristoma/Ectopia

Question 3

____ is the first node in a regional lymphatic basin that receives lymph flow from the primary tumor

Answer 3

sentinel lymph node

Question 4

Most common CA in children

Answer 4

ALL

Question 5

Most common CA in males

Answer 5

prostate

Question 6

most common CA in females

Answer 6

breast

Question 7

Most common CA that cause mortality

Answer 7

lung CA

Question 8

Type of growth factor receptor that is encoded by oncogenes

Answer 8

Tyrosine Kinase

Question 9

[name the protooncogene]

Polycythemia vera, essential thrombocytosis, primary myelofibrosis

Answer 9

JAK 2

Question 10

[name the protooncogene]

Hairy cell leukemia

Answer 10

BRAF

Question 11

[name the protooncogene]

Burkitt lymphoma, Neuroblastoma

Answer 11

MYC

Question 12

[name the protooncogene]

Glioblastoma
Melanoma

Answer 12

CDK4

Question 13

[tumor suppressor gene]
G1-S phase cell cycle checkpoint

Normally, active when hypophosphorylated

Answer 13

Rb: becomes hyperphosphorylated –> inactivated

“governor of the cell”

Question 14

[tumor suppressor gene]

this monitors the stress in the cell

activated by: anoxia, inappropriate signalling by mutated oncoproteins, DNA damage

Answer 14

p53:

“Guardian of the genome”

Question 15

Liver fluke infection that cause cholangiocarcinoma

Answer 15

Chlonorchis sinensis

Opintorchis viverrini

Question 16

HHV 5 =

Answer 16

CMV

Question 17

HHV 4

Answer 17

EBV

HHV 1 = HSV

Question 18

HHV 1 =
HHV 2 = 
HHV 3
HHV 4 
HHV 5
HHV 6
HHV 7
HHV 8

Answer 18

HHV 1 = HSV 1
HHV 2 = HSV 2
HHV 3 = VZV
HHV 4 = EBV
HHV 5 = CMV
HHV 6 = Roseola
HHV 7 = Roseola-like
HHV 8 = Kaposi

Question 19

CA associated in exposure to PVC pipes

Answer 19

Liver Angiosarcoma

Vinyl chloride in PVC pipe

Question 20

[paraneoplastic syndrome]

Cushing syndrome due to excessive ACTH or ACTH-like substances

Answer 20

Small cell lung CA
Pancreatic CA
Neural tumors

Question 21

[paraneoplastic syndrome]

SIADH due to increased ADH or ANP

Answer 21

Small cell lung CA
Oat cell lung CA
Intracranial Lung CA

Question 22

[paraneoplastic syndrome]

Hypercalcemia due to increased PTHrP, TGF alpha, TNF, IL-1

due to cancer-induced bone disease

Answer 22

Squamous cell CA
Breast CA
Renal Cell CA

Question 23

aside from thymic neoplasms, myasthenia gravis is associated with what CA

Answer 23

bronchogenic carcinoma

Question 24

[paraneoplastic syndrome]

This dermatologic manifestation is due to increased production of EGF. Associated with gastric CA, lung CA, uterine CA

Answer 24

acanthosis nigricans

Question 25

[paraneoplastic syndrome] Hypertrophic osteoarthritis Clubbing of finger

Answer 25

bronchogenic CA | Thymic neoplasm

Question 26

[paraneoplastic syndrome] | migratory thrombophlebitis due to tumor products that activate clotting

Answer 26

pancreatic CA | bronchogenic CA

Question 27

In tumor grading ang staging, this is more reflective of biologic behavior of cancer

Answer 27

cancer stage

Question 28

Abnormalities in tumor lysis syndrome

Answer 28

hyperkalemia hyperphosphatemia hyperuricemia hypocalcemia

Question 29

The most common clinical consequence of tumor lysis syndrome.

Answer 29

urate nephropathy