Neoplasia Flashcards
-oma usually connotes a benign tumor except
seminoma
lymphoma
melanoma
hepatoma
___ is a tumor-like condition where an ectopic tissue is cytologically and architecturally normal
Choristoma/Ectopia
____ is the first node in a regional lymphatic basin that receives lymph flow from the primary tumor
sentinel lymph node
Most common CA in children
ALL
Most common CA in males
prostate
most common CA in females
breast
Most common CA that cause mortality
lung CA
Type of growth factor receptor that is encoded by oncogenes
Tyrosine Kinase
[name the protooncogene]
Polycythemia vera, essential thrombocytosis, primary myelofibrosis
JAK 2
[name the protooncogene]
Hairy cell leukemia
BRAF
[name the protooncogene]
Burkitt lymphoma, Neuroblastoma
MYC
[name the protooncogene]
Glioblastoma
Melanoma
CDK4
[tumor suppressor gene]
G1-S phase cell cycle checkpoint
Normally, active when hypophosphorylated
Rb: becomes hyperphosphorylated –> inactivated
“governor of the cell”
[tumor suppressor gene]
this monitors the stress in the cell
activated by: anoxia, inappropriate signalling by mutated oncoproteins, DNA damage
p53:
“Guardian of the genome”
Liver fluke infection that cause cholangiocarcinoma
Chlonorchis sinensis
Opintorchis viverrini
HHV 5 =
CMV
HHV 4
EBV
HHV 1 = HSV
HHV 1 = HHV 2 = HHV 3 HHV 4 HHV 5 HHV 6 HHV 7 HHV 8
HHV 1 = HSV 1 HHV 2 = HSV 2 HHV 3 = VZV HHV 4 = EBV HHV 5 = CMV HHV 6 = Roseola HHV 7 = Roseola-like HHV 8 = Kaposi
CA associated in exposure to PVC pipes
Liver Angiosarcoma
Vinyl chloride in PVC pipe
[paraneoplastic syndrome]
Cushing syndrome due to excessive ACTH or ACTH-like substances
Small cell lung CA
Pancreatic CA
Neural tumors
[paraneoplastic syndrome]
SIADH due to increased ADH or ANP
Small cell lung CA
Oat cell lung CA
Intracranial Lung CA
[paraneoplastic syndrome]
Hypercalcemia due to increased PTHrP, TGF alpha, TNF, IL-1
due to cancer-induced bone disease
Squamous cell CA
Breast CA
Renal Cell CA
aside from thymic neoplasms, myasthenia gravis is associated with what CA
bronchogenic carcinoma
[paraneoplastic syndrome]
This dermatologic manifestation is due to increased production of EGF. Associated with gastric CA, lung CA, uterine CA
acanthosis nigricans
[paraneoplastic syndrome]
Hypertrophic osteoarthritis
Clubbing of finger
bronchogenic CA
Thymic neoplasm
[paraneoplastic syndrome]
migratory thrombophlebitis due to tumor products that activate clotting
pancreatic CA
bronchogenic CA
In tumor grading ang staging,
this is more reflective of biologic behavior of cancer
cancer stage
Abnormalities in tumor lysis syndrome
hyperkalemia
hyperphosphatemia
hyperuricemia
hypocalcemia
The most common clinical consequence of tumor lysis syndrome.
urate nephropathy
