Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pathology > breast > Flashcards

breast Flashcards

1
Q

painful breast is suggestive of ___ lesion

benign/malignant

A

benign

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

would you suspect cancer of the breast when the nipple discharge is spontaneous and unilateral?

A

yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

most common bacteriologic cause of acute mastitis

A

S. aureus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

[diagnosis]

mimic cancer, history of breast trauma

Histo: hemorrhagic, liquefactive fat necrosis with neutrophils and macrophages

A

fat necrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

[benign or malignant?]

Benign ductal cells
Myoepithelial cells present

A

benign

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

[diagnosis]

malignant ductal cells
present myoepithelial cells

A

DCIS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

[diagnosis]

malignant ductal cells
absent myoepithelial cells
negative p63

A

invasive CA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

[diagnosis: proliferative disease without atypia]

> 2 layers of cells in aduct
distorted lumina at periphery
mimics DCIS

A

Epithelial hyperplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

[diagnosis: proliferative disease without atypia]

solid cords or double strands of cells in a densely fibrotic stroma

closely mimics carcinoma; inner ducts are compressed

A

sclerosing adenosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

[diagnosis: proliferative disease without atypia]

papillary fronds with fibrovascular cores growing in a dilated duct

present myoepithelial layer

A

papilloma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

[diagnosis: proliferative disease without atypia]

combination of epithelial hyperplasia, sclerosing adenosis and papilloma

central nidus of entrapped glands in a hyalinized stroma

mimics cancer

A

complex sclerosing lesion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

[diagnosis: proliferative disease with atypia]

DCIS without full duct involvement
cribiform pattern (cookie cutter appearance)
A

atypical ductal hyperplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

[diagnosis: proliferative disease with atypia]

LCIS but less than 50% involvement of acini in a lobule; loss of E-cadherin

A

Atypical lobular hyperplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

most common non-skin malignancy in women

A

breast CA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

2nd to lung CA in causing deaths in women

A

breast CA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

BRCA 1 is located in what chroomosome?

A

Ch 17

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

BRCA 2 is located in what chroomosome?

A

Ch 13

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

the duct system of that breast that is hormonally responsive

A

terminal duct-lobular unit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

site in the breast where invasive breast CA arise

A

terminal duct-lobular unit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

[diagnosis: cancer or not CA?]

small, irregular, numerous, clustered calcification

A

CA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

[diagnosis: comedo vs non comedo DCIS]

high grade nuclei, central necrosis

A

comedo DCIS

22
Q

[diagnosis: comedo vs non comedo DCIS]

variable nuclear grade and architectural pattern

A

non comedo DCIS

23
Q

[diagnosis: comedo vs non comedo DCIS]

ducts filled with cells with high grade nuclear atypia, central necrosis

A

comedo

24
Q

[diagnosis: comedo vs non comedo DCIS]

ducts completely filled with cell, appearing as solid nets

A

non-comedo, solid

25
Q

[diagnosis: comedo vs non comedo DCIS]

ducts filled with cells with secondary lumina

A

non-comedo, cribiform

26
Q

[diagnosis: comedo vs non comedo DCIS]

bulbous projections WITHOUT fibrovascular cores

A

non-comedo, micropapillary

27
Q

[diagnosis: comedo vs non comedo DCIS]

papillary fronds WITH fibrovascular cores but NO myoepithelial layer in fronds

A

papillary

28
Q

[diagnosis: CA]

monomorphic cellular appearance, distinct cytoplasmic borders, pale cytoplasm, round nuclei, absent streaming, CK5 (+), CK 6 (-), ER (+), diffuse

A

DCIS

29
Q

[diagnosis: CA]

heterogenous appearance, indistinct borders, eosinophilic cytoplasm, oval nuclei, present streaming, CK5 (+) CK6 (+), ER (+), mosaic

A

epithelial hyperplasia

30
Q

[diagnosis: CA]

unilateral eruption with a scale crust, pruritic, malignant cell reaches the ductal cell without violating the basement membrane

A

paget cells

31
Q

[diagnosis: CA

intact basement membrane, no disruption of lobules, absent necrosis, nipple of the skin not involved, ER(+), PR(+), HER2(-)

A

LCIS

32
Q

most common type of invasive carcinoma of the breast

A

invasive breast CA, no special type

33
Q

[diagnosis: infiltrating carcinoma]

in situ with absence of myoepithelial layer, haphazarly disposed cells with desmoplasia

A

invasive breast CA, no special type

34
Q

[diagnosis: infiltrating carcinoma]

E-cadherin loss, ER/PR (+), HER2 (-), little desmoplasia, indian file/ dyscohesive infiltrating tumor cells in single file

mucin (+)

A

invasive lobular carcinoma

35
Q

[diagnosis: infiltrating carcinoma]

clusters of small islands of tumor cells floating in pools of extracellular mucin, low atypia

ER/PR(+), HER2 (-)

A

mucinous (colloid) carcinoma

36
Q

[diagnosis: infiltrating carcinoma]

syncitium-like solid sheets of large cells with pleomorphic nuclei and prominent nucleoli, increased mitosis, lymphoplasmatic infiltrates, pushing borders

ER(-) HER2(-)

A

medullary carcinoma

37
Q

[diagnosis: infiltrating carcinoma]

extensive invation and proliferation within lymphatic channels, presents as swelling that can mimics non-neoplastic inflammatory disorder

A

inflammatory CA

38
Q

this test is done to confirm positivity to HER2 in cases of equivocal result

A

FISH

fluorescence in situ hybridization

39
Q

[diagnosis: drug treatment for this subtype/molecular subtype]

ER(+)
Her2(-)
Ki67 low

A

Luminal A, tamoxifen

40
Q

[diagnosis: drug treatment for this subtype/molecular subtype]

ER(+)
Her2(-)
Ki67 high

A

Luminal A, tamoxifen

41
Q

[diagnosis: drug treatment for this subtype/molecular subtype]

ER(+/-)
PR(+/-)
Her2(+)
Ki67 high

A

Her 2 enriched, Trastuzumab

42
Q 
[diagnosis: drug treatment for this subtypemolecular subtype]
 in study
ER(-)
Her2(-)
Ki67 high
A

Basal

43
Q

most common benign tumor of the female breast

A

fibroadenoma

44
Q

[diagnosis: stromal tumor]

older females, larger breast mass

stromal overgrowth, infiltrative boarders, high cellularity, high mitosis, nuclear pleomorphism, leaf-like projections

A

phyllodes tumor

45
Q

[diagnosis: type of phyllodes tumor]

Well defined borders, fibroblastic appearance, little to mild atypia, <5 mitoses/10HPF, no stromal overgrowth

A

benign phyllodes tumor

46
Q

[diagnosis: type of phyllodes tumor]

focally infiltrative borders, moderate cellularity, moderate atypia, 5-9 mitoses/10HPF, no stromal overgrowth or focal stroma

A

borderline phyllodes tumor

47
Q

[diagnosis: type of phyllodes tumor]

infiltrative borders, high cellularity, marked atypia, >/10 mitoses/10HPF, with stromal overgrowth

A

malignant phyllodes

48
Q

[diagnosis: type of phyllodes tumor]

metaplastic elements containing bone, skeletal, cartilage tissues

A

malignant phyllodes

49
Q

[diagnosis: type of phyllodes tumor]

4 LPO field shows only stromal component

A

malignant phyllodes

50
Q

[diagnosis: stromal tumors]

young female, relatively smaller breast mass

stromal proliferation = epithelial lesion, lesser stromal cellularity, not atypia, no mitosis

A

fibroadenoma

51
Q

in gynecomastia, the duct lining undergoes ___ (hypertrophy/hyperplasia)

A

hyperplasia

Pathology (36 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions