Environmental Pathology

Question 1

Ozone injures ___ type of pneumocytes via free radical formation

Answer 1

type I

Question 2

cut off value for particulate matter that are more dangerous because it can travel to distal air spaces

Answer 2

<10um

Question 3

CO inhibits what complex of the ETC

Answer 3

Complex IV or the Cyt C oxidase

Question 4

Chronic CO poisoning affect which part of the CNS

Answer 4

basal ganglia and lenticular nuclei

Question 5

heavy metal that inhibits ALA dehydratase and ferrochelatase

Answer 5

Lead

Question 6

microcytic, hypochromic, anemia with hemolysis.

This is associated with ___ poisoning

Answer 6

lead

Question 7

In lead poisoning among adults, which comes first, foot drop or wrist drop?

Answer 7

wrist drop.

lead causes peripheral demyelinating neuropathy

Question 8

[heavymetal poisoning]

saturnine gout

Answer 8

lead

Question 9

[heavymetal poisoning]

cerebral palsy, blindness, mental retardation, major CNS defect in utero exposure

Answer 9

methylmercury

minimata disease

Question 10

“king of poisons”

“poison of kings”

Answer 10

Arsenic

Question 11

Chronic exposure to this heavymetal can lead to hyperpigmentation and hyperkeratosis. usually affects palms and soles

Answer 11

Arsenic

Question 12

[name the causative heavymetal agent]
osteoporosis
osteomalacia
renal disease

Answer 12

cadmium

itai-itai disease

Question 13

what component of tobacco has the most carcinogenic effect

Answer 13

nitrosamine

Question 14

Alcohol is metabolized by these enzymes to for acetaldehyde

Answer 14

CYP2E1 (MEOS
Alcohol dehydrogenase (main enzyme)
Catalase

Question 15

[burn classification]

pink, mottled with blisters.

which layer/s of the skin is/are involved

Answer 15

Epidermis and dermis

2nd degree, partial thickness

Question 16

[burn]

coagulative necrosis and inflammatory cell exudation are present in these burn stages

Answer 16

2nd and 3rd degree

Question 17

[hyperthermia syndrome]

failure of CVS to compensate for hypovolemia from dehydration

Answer 17

heat exhaustion syndrome

Question 18

this condition presents as heat-stroke-like symptoms after exposure to halothane

Answer 18

malignant hyperthermia

Question 19

exposure of p53 in ionizing radiation causes its _____ (up/downregulation)

Answer 19

upregulation