Blood Vessels Pathology Flashcards
[syndrome]
gain of function of ENaC channel resulting to increased Na reabsorption and then hypertension
Liddle Syndrome
Associated condition
eosinophilic hyaline material with associated luminal narrowing
essential hpn
DM
[associated condition]
concentric, laminated thickening, onion skin lesion, note of fibrinoid deposition and vessel wall necrosis
malignant hypertension
location of neovascularization in an atheromatous plaque
periphery
[clinical phase of atherosclerosis]
mural thrombosis, embolization, and wall thickening can lead to
aneurysm and rupture
[clinical phase of atherosclerosis]
plaque rupture, plaque erosion, plaque hemorrhage, mural thrombosis, embolization can lead to
occlusion by thrombus
[clinical phase of atherosclerosis]
progressive plaque growth can lead to
critical stenosis
usually 70%
the larger the lipid core, the ____stability of the plaque
greater the stability of the plaque
Remember, size of lipid core is inversely proportional to stability
the lesser the degree of inflammation, the ____ stability of the plaque
greater stability
remember, degree of inflammation is inversely proportional to stability
the thicker the fibrous cap, the ___ stable the plaque
more stable the plaque
fibrous cap is directly proportional to stability
[dissection]
intima tear involvinf the descending aorta only.
What is the standford classification?
Stanford B
DeBakey III = Standford B
[aortic dissection]
Both ascending and descending aorta are involved.
What is it s debakey classification?
DeBakey I
[diagnosis?]
45/M, hypertensive with marfan syndrome.
Noted sudden, excruciating anterior chest pain, radiating to the back and downward
aortic dissection
[syndrome]
Non-infectious small artery vasculitides, p-anca positive
churg-strauss syndrome
[syndrome]
non-infectious small artery vasculitides, c-anca positive
Wegener granulomatosis/ granulomatosis with polyangitis
[diagnosis]
headache among elderly individual, along course of superficial temporal artery, associated with multiple joint pains
giant cell arteritis
[diagnosis]
affects large vessels of the aortic arch, notable ocular disturbances and weakened UE pulses
takayasu
[diagnosis]
associated with hepatitis B, renal and visceral vessels (NEVER PULMONARY)
clinically, HPN and visceral ischemia
prominent fibrinoid necrosis, segmental, transmural, necrotizing
polyarteritis nodosa
[diagnosis]
fever >5 days, conjunctival injection, mucosal erythema, cervical lymphadenopathy, polyamorphous exanthem
kawasaki disease
important cause of MI in children; can cause coronary artery aneurysm
less prominent fibrinoid necrosis, segmental, transmural, necrotizing
kawasaki disease
[diagnosis]
associated with connective tissue disorders
common in kidney and LUNG; hemoptysis, hematuria
microscopic polyangitis
PAN = no lung involvement
[diagnosis]
associated with asthma, allergic rhinitis, eosinophilia
noted involvement of cutaneous, GIT, renal and cardiac vessel
Clinically, palpable purpura, GI bleed and FSGS
churg-strauss syndrome
[diagnosis]
PAN + extravascular necrotizing granulomas and hypereosinophilia
Churg-strauss syndrome
Remember, atopy/eosinophilia = sneeze = aaachooo = aaaachurg
[diagnosis]
fragmented PMNs in post capillary venule (leukocytolasia)
Microscopic polyangitis
[diagnosis]
prominent pulmonary involvement, may also involve renal vessels necrotizing granulomas of respiratory tract, necrotizing or granulomatous vasculitis, focal segmental necrotizing GN
c-ANCA positive
Wegener granulomatosis
[diagnosis]
recurrent oral aphthous ulcers, genital ulcers, uveitis, neutrophilic infiltration of vessels
small to medium sized vessels are affected
Behcet syndrome
[diagnosis]
strongly associated with cigarette smoking, small to medium vessel involvement, reynaud phenomenon, intermittent claudication, thrombosis with microabcesses
buerger disease
Thromboangitis obliterans
most important risk factor for lower extremity DVT
prolonged immobilization
[diagnosis]
migratory superficial vein thrombophlebitis in cancer patient
trosseau syndrome
[diagnosis]
lower extremity edema, superficial abdominal vein distention, massive proteinuria (if renal vein is involved)
IVC syndrome
most common cause of lymphangitis and lymphedema
GABHS
[diagnosis]
facial port wine nevi, ipsilateral leptomeningeal cortical venous angiomas, mental retardation, seizures, hemiplegia, skull radioopacities
Struge-Weber syndrome
[diagnosis]
AD defect in TGF beta
telangectasia on skin, oral mucosa, respiratory, GIT, urinary tract
Osler-weber-rendu disease
[diagnosis]
rapidly growing, red, pedunculated lesion on the skin, gingival or oral mucosa
pyogenic granuloma
cavernous lymphangiomas of the neck is more common in ___ syndrome
Turner
[diagnosis]
african, <40 years old, HIV negative, HHV 8
Endemic Kaposi Sarcoma
[diagnosis]
HHV 8 in HIV positive patients
epidemic kaposi sarcoma
Thorotrast exposure is associated with this malignant tumor
hepatic angiosarcoma
Stains used in angiosarcomas
CD31, CD34, vWF
