Cellular Response to Stress

Question 1

Nuclear changes in necrosis

Answer 1

Pyknosis –> Karyorrhexis –> karyolysis

Question 2

Pubertal breast changes is an example of physiologic ____ (hyperplasia/hypertrophy)

Answer 2

Hyperplasia

Question 3

Architecture is not preserved in this kind of necrosis

Answer 3

caseous

Question 4

In intrinsic pathway of apoptosis, BCL2 is ____ (activated, inactivated) while BAX/BAK channel is ____ (activated, inactivated)

Answer 4

Inactivated BCL2

Activated BAX/BAK

Question 5

Caspase 8 and 10 are initiator caspases of which apoptotic pathway

Answer 5

Extrinsic

Intrinsic: Caspase 9

Question 6

Executioner caspases are caspase ___ and ____

Answer 6

3 and 6

Question 7

Intracellular hyaline that is PAS positive, diastase resistant is a characteristic of ___ disease

Answer 7

alpha 1 antitrypsin deficiency

Question 8

PAS postive, diastase-sensitive glycogen granule in hepatocyte is characteristic of what disease?

Answer 8

DM

Question 9

Onchronosis is due to the endogenous production of

Answer 9

Homogentisic acid (alkaptonuria)

Question 10

Enzymes that are adapted to food deprivation, increases cellular longevity, and activation of DNA repair mechanism

Answer 10

sirtuins