Inflammation and Repair Flashcards
Cite the proper sequence of Recruitment of Leukocytes to sites of inflammation
Margination, Rolling, Adhesion, Transmigration (Diapedesis), migration
Interleukin that mediates leukocyte recruitment
IL 1
___ is a leukocyute-endothelial process that is weak, transient,
Rolling
____ is the main adhesion molecule during diapedesis
CD31/PECAM-1
Endogenous compounds that play a role in chemotaxis
IL-8, C5a, LTB4
What is the dominant infiltrate during a pseudomonas infection
PMNs for several days
What is the ligand of selectins?
Sialyl-Lewis X
Cite 3 examples of removing the pathologic agent
Intracellular (ROS, NO)
Lysosomal enzymes
Neutrophil extracellular traps (NETs)
____ are anti-inflammatory cytokines
Lipoxin (AA metabolite)
TGF beta
IL 10
Bega10 = mataba = lipid = lipoxin
____ is found in platelets and neuroendocrine cells that is a potent vasoconstrictor
Serotonin (derived from tryptophan)
The enzyme cyclooxygenase produces ___ and ____ from AA
Prostanoids (Vasodilators)
Thromboxane (Vasoconstrictor)
____ are eicosanoids that increases vascular permeability and causes bronchospasm
LTC4, D4, E4
Inhibited by LTRAntagonist
___ prostanoids that causes vasodilation, and inhibits platelet aggregation
Prostacyclin (PGI2)
___ prostanoids that causes vasoconstriction, promotes platelet aggregation
Thromboxane A2
TXA2 = X = shrink
___ prostanoids that causes vasodilation, increases vascular permeability
PGD2, PGE2
PGD = drains
Cytokine that plays a role in acute inflammation specifically in recruiting neutrophils and monocytes
IL 17
Cytokine in chronic inflammation that acts on macrophages and dendritic cells resulting to increased production of IFN gamma
IL12
____ pathway in complement system in which C1 binds to Ig-Ag complex
classical
___ pathway in complement system that depends on microbial components
alternative
___ is the most abundant component in complement systems
C3
Anaphylatoxins in complement pathway which promotes histamine release from mast cells
C3a, C5a
C5a are chemoattractants to neutrophils, monocytes, eosinophils and basophils
Component of complement pathway that are part of MAC
C5b, C6-9
Cytokines that plays a role in endothelial activation, fever, hypotension, and metabolic abnormalities
TNF, IL-1, IL-6
___ is the hallmark of granuloma formation
presence of epithelioid cells or giant cells
IL 6 dominates during an acute phase response. This will lead to increase in
CRP, Fibrinogen, Amyloid A
___ is the most important cytokine for synthesis and deposition of connective tissue
TGF-beta
[Abnormalities in tissue repair]
Inadequate formation of granulation tissue
Wound dehiscence
____ is the excessive formation of repair components extending beyond the border of the lesion
keloid
