Uterine Drugs Flashcards
Albuminuria
Excessive protein in the urine
Antepartum
The time during pregnancy before childbirth
Eclampsia
A condition where seizures and possible coma happen in pregnancy after 20 weeks in a woman who has become hypertensive, with excess protein found in the urine
Placenta previa
During pregnancy, the placenta implants in the lower part of the uterus, possibly over the cervix
Preeclampsia
A condition in pregnancy after 20 weeks, in a woman when she becomes hypertensive with excess protein found in the urine
Tocolysis
To prevent preterm labor
Uterine atony
Marked relaxation of the uterine muscle
Water intoxications
Fluid overload in the body when electrolytes are imbalanced
Oxytocin MOA
Has uterus stimulating properties, and stimulates contractions. Also has antidiuretic and vasopressor effects
Oxytocin use
Starting or improving labor contractions, induce an early vaginal delivery when there are fetal or maternal problems such as, diabetes, large fetus, Rh Problems, premature membrane rupture, uterine inertia, and preeclampsia, managing abortion,
Preeclampsia signs
Hypertension, headache, albuminuria, edema of the lower extremities occurring at or near term, and this condition may progressively worsen until eclampsia
Oxytocin administration
IV, but if that isn’t available, can be given IM during the 3rd stage of labor to produce uterine contractions and control postpartum bleeding and lessen hemorrhage potential. Intranasally, may stimulate milk ejection reflex
Uterine stimulants MOA
Increase strength, duration, and frequency of uterine contractions
Uterine stimulants use
Decrease the incidence of postpartum and postabortal hemorrhage caused by uterine atony (given after delivery of placenta)
Metoclopramide alternate use
Producing a greater milk supply (variable success)
Oxytocin side effects for mother
Nausea, vomiting, cardiac arrhythmias, anaphylactic reactions, uterine rupture, uterine hypertonicity, serious water intoxication (esp when administered by continuous infusion and fluids are being received by mouth )
Oxytocin reactions fetus
Bradycardia
Uterine stimulants side effects mother
Nausea, vomiting, diarrhea, high blood pressure, temporary chest pain, dizziness, water intoxication, headache, allergic reaction, hypertension associated with seizure or headache
Oxytocin contraindications
Cephalopelvic disproportion, unfavorable fetal position or presentation, obstetric emergencies, fetal distress where delivery isn’t imminent, severe preeclampsia, eclampsia, hypertonic uterus, total placenta previa
Oxytocin interactions
Severe maternal hypertension with vasopressors
Methylergonovine contraindications
Not used before delivery of fetus, hypertension,
Carboprost contraindications
Before delivery of fetus, hypertension
Misoprostol as a uterine stimulant contraindications
Hypertension, before delivery of fetus
Methylergonovine precautions
Heart disease, vascular disease with narrowed vessels, renal or hepatic disease, lactation
Carboprost precautions
Heart disease, vascular disease with narrowed blood vessels, renal or hepatic disease and lactation.
Misoprostol as a uterine stimulant precautions
Heart disease, vascular disease with narrowing of blood vessels, renal or hepatic disease, lactation
Methylergonovine interactions
Excessive vasoconstriction with vasopressors or to people that are heavy smokers
Primary treatments to stop PTL
Progesterone and rest
When are tocolytics indicated
Rate of contractions is more than 6 per hour and produce cervical charges
Indomethacin as a tocolytic MOA
Blocks the production of prostaglandins, which contribute to uterine contractions
Magnesium MOA as a tocolytic
Calcium antagonist, and decrease the force of contractions
Nifedipine as a tocolytic use
Used to delay the delivery process for 24-48 hours
Tocolytic side effects to the mother
Fatigue, flushing, headache, dizziness, diplopia, nausea, vomiting, stomach upset, heartburn, prolonged vaginal bleeding, sweating, hypotension, depressed reflexes, Flaccid paralysis , and hypocalcemia
Tocolytics side effects to the fetus
Increased heart rate and increase blood sugar
Magnesium as a tocolytic contraindications
Heart block, myocardial infarction, when woman is within 2 hours of delivery
Magnesium pregnancy cat
A
CCBs as tocolytics contraindications
Heart block, myocardial infarction, and when woman is within 2 hours of delivery
Terbutaline as a tocolytic contraindications
Heart disease, hyperthyroid, poorly controlled diabetes
CCBs pregnancy cat
C
Indomethacin pregnancy cat
B
Terbutaline as a tocolytic considerations
Because of the risk of side effects, terbutaline for more than 48 hours in the home isn’t advised and oral form isn’t recommended for use as a tocolytic
Magnesium interactions
Increased effectiveness of CNS depressants, and the effectiveness of neuromuscular blocking drugs is enhanced
Oxytocics ex
Carboprost, methylergonovine, misoprostol, oxytocin
Agents for cervical ripening ex
Dinoprostone
Tocolytics ex
Nifedipine, indomethacin, magnesium, terbutaline
