Psycotropics Flashcards
SSRI basics
Selective serotonin reuptake inhibitors, type of antidepressant (often first given)
SSRIs ex
-xetine: paroxetine(very common), fluoxetine(very common), sertraline, citalopram, escitalopram, fluvoxamine, vilazodone, vortioxetine
SSRIs time to take effect
4-6 weeks
SSRIs side effects
Somnolence, dizziness, headache, insomnia, tremor, weakness, constipation, dry mouth, nausea, pharyngitis, runny nose, urinary retention, abnormal ejaculation
Benzodiazepines purpose
Anxiety reducing, hypnotic, sedative, anticonvulsant (short term only)
Benzodiazepine ex
-zepam, -Zolam: diazepam (anxiety and seizures), temazepam (sleep), alprazolam (anxiety and nerves), midazolam (anesthesia), triazolam(sleep) CNS DEPRESSION
Benzodiazepines concerns
Respiratory depression, risk of addiction
CNS stimulants MOA
Enhance dopamine transmission to areas of the brain that interpret well being
CNS stimulants side effects
Agitation, insomnia, headache, dizziness, apprehension, disorientation, hyperactivity, nausea, vomiting, dyspnea, urinary retention, tachycardia, palpitation
CNS stimulants concerns
High risk of abuse and tolerance
Bupropion indications
Depression, SAD, smoking cessation
Bupropion MOA
Increases dopamine and norepinephrine
Bupropion side effects
Stimulant, seizures
SNRIs indications
Depressive episodes, depression accompanied by anxiety disorders (GAD, panic, social phobias, PTSD), diabetic peripheral neuropathic pain, fibromyalgia, and chronic muscle pain
SNRIs example
Duloxetine and venlafaxine, bupropion, tradozone, nefazodone, maprotiline
SNRIs side effects general
Fatigue, tachycardia, palpitations, change in libido, impotence, skin rash, itching, vasodilation resulting in sweating and excessive sweating
TCAs indications and full form
Tricyclic antidepressants, for depression, OCD, bipolar, chronic neuropathic pain, depression accompanied by anxiety disorders, enuresis
TCAs ex
-iptyline or -ipramine: amitriptyline, desipramine, clomipramine, imipramine, nortriptyline + doxepin, amoxapine,
TCAs side effects
Anticholinergic, 3 C’s convulsion, coma, cardiotoxicity, + constipation and photosensitivity
MAOIs full form
Monoamine oxidase inhibitors
MAOIs indications
Depressive episodes
MAOIs aren’t for
Elderly, pheochromocytoma, liver and kidney disease, cerebrovascular disease, hypertension, history of headaches,
MAOIs ex
Takes Pride In Shanghai: Tranylcypromine, Phenelzine, Isocarboxazid, Selegiline
Aripiprazole indications
Schizophrenia, bipolar disorder, depression
Aripiprazole side effects
Headache, dizziness, nausea, insomnia, anxiety
Aripiprazole facts
Lowest risk of weight gain, lowest risk of drug induced disorders
Antipsychotics indication
Tourette’s and schizophrenia, bipolar, agitation and behavioral disorders
Antipsychotics MOA
Block dopamine receptors
Antipsychotics side effects
Sedation, headache, hypotension, dry mouth, nasal congestion, urticaria, photophobia, photosensitivity, increase in the intensity of the psychotic symptoms, lethargy, hyperactivity, paranoid reactions, agitation, confusion, weight gain, increased cholesterol, triglyceride, and blood sugar levels, neuroleptic malignant syndrome, recidivism
Low potency antipsychotics ex and side effects
Chlorpromazine (SE: corneal deposit and cataracts) and thioridazine( SE: corneal deposits and cataracts)
High potency antipsychotics ex
Fluphenazine, trifluoperazine, haloperidol
High potency antipsychotics side effects
Short term: dystonia, torticolis
Long term: tardive dyskinesia
Atypical antipsychotics indications
Schizophrenia
Atypical antipsychotics side effects
Seizures, prolonged QT interval, agranulocytosis
Neuroleptic malignant syndrome signs and symptoms
FEVER: fever, encephalopathy, vital signs unstable, elevated enzymes, rigidity of muscles
Reverse neuroleptic malignant syndrome by
D2 Agonists (bromocriptine, dantrolene)
Haloperidol indications
Migraines and schizophrenia
Haloperidol side effects
QT prolongation, weight gain, restlessness, neuroleptic malignant syndrome
Haloperidol concerns
Caution in seizure patients
Chlorpromazine classification
Low potency antipsychotic
Chlorpromazine indication
Schizophrenia and hiccups
Chlorpromazine side effects
Corneal deposits, cataracts, hypotension, sedation, neuroendocrine effects
Clozapine classification
Atypical antipsychotic
Clozapine indication
Schizophrenia, and levodopa induced psychosis
Clozapine consideration
Need weekly lab tests
Clozapine side effects
Hypersalivation, myocarditis, arangulocytosis
Pregablin MOA
GABA analog
Pregablin indications
Seizures, neuropathic pain, fibromyalgia
Pregablin side effects
Fatigue, angioedema, rhabdomylolysis (breakdown of muscle tissue)
Pregablin risks
Dependence potential
Risperidone classification
Atypical antipsychotic
Risperidone indications
Schizophrenia, bipolar mania, autism associated irritability
Risperidone side effects
Prolonged QT, hyperprolactinemia, gynecomastia, amenorrhea
Risperidone administration fact
IM= long lasting form
Lithium classification
Atypical antipsychotic
Lithium indications
Bipolar (mood stabilizer)
Lithium restrictions
Not for use during pregnancy (cat
D), allergy to tartrazine, renal or cardiovascular disease, sodium depletion, dehydration in patients taking diuretics, lactation
Lithium side effects
Tremors, nausea, vomiting, thirst, polyuria
Tardive dyskinesia symptoms
Bizarre facial movements, bizarre tongue, increased extremity movements, stiff neck, dysphagia
Tardive dyskinesia solutions
Stop meds, AIMS
Cholinesterase inhibitors MOA
Block breakdown of acetylcholine
Cholinesterase inhibitors indications
Dementia, Alzheimer’s (early and moderate stages)
Cholinesterase inhibitors side effects
Vasodilation, constriction of pupils, slow HR, mucus in respiratory tract, anorexia, nausea, vomiting, diarrhea, dizziness, headache
Cholinesterase inhibitors ex
Memantine, galantamine, donepazil, rivastigmine,
Barbiturates indications
Seizure treatment and anesthesia
Barbiturates MOA
Decrease neuron firing, increase duration of Cl channel opening.
Barbiturates SE
Sedation CNS depression, CV depression, respiratory depression, P450 inhibitor
Phenobarbital indications
Seizures
Phenobarbital side effects
Ataxia, paradoxical excitement
Phenobarbital considerations
High abuse potential
Zolpidem classification
Non benzodiazepine hypnotic
Zolpidem indications
Insomnia
Zolpidem MOA
GABA receptor
Zolpidem side effects
Ataxia and confusion
Zolpidem considerations
Lower chance of dependence
Buspirone indication
General anxiety
Buspirone MOA
5-HTIA receptors, release dopamine and norepinephrine
Buspirone considerations
Little side effects, no alcohol interaction
Tradozone indication
Insomnia
Tradozone MOA
Alpha blocker: inhibit serotonin reuptake
Tradozone side effects
Sedation, priapism, orthostatic hypotension
Acetylcholine
Neurotransmitter that sends impulses across the parasympathetic branch of the autonomic nervous system
Amyloid plaque
Tangles of protein in nerve tissue
Parasympathetic
Pertaining to the part of the autonomic nervous system concerned with conserving body energy