Adrenergic Blocking Drugs Flashcards

1
Q

Alpha adrenergic

A

Alpha receptors of the adrenergic nerves that control the vascular system

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2
Q

Anti adrenergic

A

Blocks the neurotransmission of the sympathetic nervous system

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3
Q

Beta adrenergic

A

Beta receptors of the adrenergic nerves that primarily control the heart

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4
Q

Cardiac arrhythmia

A

Abnormal rhythm of the heart aka cardiac dysrhythmia

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5
Q

First dose effects

A

Marked adverse reaction with the first dose

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6
Q

Orthostatic hypotension

A

Decrease in blood pressure occurring after standing in one place for an extended period

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7
Q

Pheochromocytoma

A

Tumor of the adrenal medulla characterized by the hypersecretion of epinephrine and norepinephrine

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8
Q

Sympatholytic

A

Blocking the sympathetic nervous system

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9
Q

Alpha adrenergic blocking drugs MOA

A

Causes vasodilation by relaxing the smooth muscle of blood vessels

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10
Q

Alpha adrenergic blocking drugs uses

A

Hypertension during preoperative preparation, hypertension caused by pheochromocytoma, prevent or treat tissue damage caused by extravastation of the drug dopamine

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11
Q

Alpha adrenergic blocking drug adverse reactions

A

Weakness, orthostatic hypotension, cardiac arrhythmias, hypotension, and tachycardia

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12
Q

Alpha adrenergic blocking drugs contraindications

A

Coronary artery disease

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13
Q

Alpha adrenergic blocking drugs precautions

A

Pregnancy (cat C), lactation, after a recent myocardial infarction, and with renal failure or a Raynaud disease

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14
Q

Alpha adrenergic blocking drugs interactions

A

When phenylalanine in’s given with epinephrine, there is decreased vasoconstrictor and hypertensive action

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15
Q

Alpha/beta adrenergic blocking drugs MOA

A

Block stimulation of both alpha and beta adrenergic receptors, resulting in peripheral vasodilation

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16
Q

Alpha/beta adrenergic blocking drugs ex

A

Carvedilol and labetalol

17
Q

Carvedilol use

A

Hypertension and in heart failure

18
Q

Labetalol uses

A

Hypertension, can be used in combination with diuretics

19
Q

Alpha/beta adrenergic blocking drugs side effects

A

Generally mild, include fatigue, dizziness, hypotension, drowsiness, insomnia, weakness, diarrhea, dyspnea, chest pain, bradycardia, and skin rash

20
Q

Alpha/beta adrenergic blocking drugs contraindications

A

Bronchial asthmas, decompensated heart failure, severe bradycardia

21
Q

Alpha/beta adrenergic blocking drugs precautions

A

Drug controlled heart failure, chronic bronchitis, impaired hepatic or cardiac function, diabetes, pregnancy (cat C), lactation

22
Q

Alpha/beta adrenergic blocking drugs interactions

A

SSRIs ad TCAs increase risk of tremors, cimetidine increases adrenergic blocker effect, increased effect of clonidine, increased serum levels of digoxin and higher risk of digoxin toxicity

23
Q

Peripherally acting adrenergic blocking drugs MOA

A

Act on peripheral structures

24
Q

Prazosin indications

A

Hypertension

25
Q

Centrally acting adrenergic blocking drug MOA

A

Act on CNS

26
Q

Centrally acting adrenergic blocking drugs ex

A

Clonidine, guanabenz, guanfacine, methyldopa

27
Q

Peripherally acting adrenergic blocking drugs ex

A

Prazosin, reserpine, alfuzosin, doxazosin, silodosin, tamsulosin, terazosin

28
Q

Centrally and peripherally acting adrenergic blocking drugs use

A

Cardiac arrhythmia, hypertension, and benign prostatic hyperplasia

29
Q

Centrally acting adrenergic blocking drugs side effects

A

Dry mouth, drowsy, sedation, anorexia, rash, malaise, weakness

30
Q

Peripherally acting adrenergic blocking drugs

A

Hypotension, weakness, lightheadedness, bradycardia

31
Q

Reserpine contraindications

A

Active peptic ulcer, ulcerative colitis, mentally depressed

32
Q

Reserpine precautions

A

History of depression, renal impairment, cardiovascular disease, and during pregnancy and lactation

33
Q

Centrally acting adrenergic blocking drugs contraindications

A

Active hepatic disease, using MAOIs

34
Q

Centrally acting adrenergic blocking drugs precautions

A

History of liver disease, renal impairment, pregnancy and lactation

35
Q

Centrally and peripherally acting adrenergic blocking drugs interactions

A

Adrenergic drugs increase risk of hypertension, decreased effect of levodopa and hypotension, increased effect of anesthetic agents, beta blockers increase risk of hypertension, increased risk of lithium toxicity, increased risk of psychotic behavior with haloperidol

36
Q

Alpha adrenergic blocking drugs ex

A

Phentolamine