Adrenergic Blocking Drugs Flashcards
Alpha adrenergic
Alpha receptors of the adrenergic nerves that control the vascular system
Anti adrenergic
Blocks the neurotransmission of the sympathetic nervous system
Beta adrenergic
Beta receptors of the adrenergic nerves that primarily control the heart
Cardiac arrhythmia
Abnormal rhythm of the heart aka cardiac dysrhythmia
First dose effects
Marked adverse reaction with the first dose
Orthostatic hypotension
Decrease in blood pressure occurring after standing in one place for an extended period
Pheochromocytoma
Tumor of the adrenal medulla characterized by the hypersecretion of epinephrine and norepinephrine
Sympatholytic
Blocking the sympathetic nervous system
Alpha adrenergic blocking drugs MOA
Causes vasodilation by relaxing the smooth muscle of blood vessels
Alpha adrenergic blocking drugs uses
Hypertension during preoperative preparation, hypertension caused by pheochromocytoma, prevent or treat tissue damage caused by extravastation of the drug dopamine
Alpha adrenergic blocking drug adverse reactions
Weakness, orthostatic hypotension, cardiac arrhythmias, hypotension, and tachycardia
Alpha adrenergic blocking drugs contraindications
Coronary artery disease
Alpha adrenergic blocking drugs precautions
Pregnancy (cat C), lactation, after a recent myocardial infarction, and with renal failure or a Raynaud disease
Alpha adrenergic blocking drugs interactions
When phenylalanine in’s given with epinephrine, there is decreased vasoconstrictor and hypertensive action
Alpha/beta adrenergic blocking drugs MOA
Block stimulation of both alpha and beta adrenergic receptors, resulting in peripheral vasodilation
Alpha/beta adrenergic blocking drugs ex
Carvedilol and labetalol
Carvedilol use
Hypertension and in heart failure
Labetalol uses
Hypertension, can be used in combination with diuretics
Alpha/beta adrenergic blocking drugs side effects
Generally mild, include fatigue, dizziness, hypotension, drowsiness, insomnia, weakness, diarrhea, dyspnea, chest pain, bradycardia, and skin rash
Alpha/beta adrenergic blocking drugs contraindications
Bronchial asthmas, decompensated heart failure, severe bradycardia
Alpha/beta adrenergic blocking drugs precautions
Drug controlled heart failure, chronic bronchitis, impaired hepatic or cardiac function, diabetes, pregnancy (cat C), lactation
Alpha/beta adrenergic blocking drugs interactions
SSRIs ad TCAs increase risk of tremors, cimetidine increases adrenergic blocker effect, increased effect of clonidine, increased serum levels of digoxin and higher risk of digoxin toxicity
Peripherally acting adrenergic blocking drugs MOA
Act on peripheral structures
Prazosin indications
Hypertension
Centrally acting adrenergic blocking drug MOA
Act on CNS
Centrally acting adrenergic blocking drugs ex
Clonidine, guanabenz, guanfacine, methyldopa
Peripherally acting adrenergic blocking drugs ex
Prazosin, reserpine, alfuzosin, doxazosin, silodosin, tamsulosin, terazosin
Centrally and peripherally acting adrenergic blocking drugs use
Cardiac arrhythmia, hypertension, and benign prostatic hyperplasia
Centrally acting adrenergic blocking drugs side effects
Dry mouth, drowsy, sedation, anorexia, rash, malaise, weakness
Peripherally acting adrenergic blocking drugs
Hypotension, weakness, lightheadedness, bradycardia
Reserpine contraindications
Active peptic ulcer, ulcerative colitis, mentally depressed
Reserpine precautions
History of depression, renal impairment, cardiovascular disease, and during pregnancy and lactation
Centrally acting adrenergic blocking drugs contraindications
Active hepatic disease, using MAOIs
Centrally acting adrenergic blocking drugs precautions
History of liver disease, renal impairment, pregnancy and lactation
Centrally and peripherally acting adrenergic blocking drugs interactions
Adrenergic drugs increase risk of hypertension, decreased effect of levodopa and hypotension, increased effect of anesthetic agents, beta blockers increase risk of hypertension, increased risk of lithium toxicity, increased risk of psychotic behavior with haloperidol
Alpha adrenergic blocking drugs ex
Phentolamine