Urinary Tract Anti-infectives Flashcards
Cystitis
Bladder inflammation
Prostatitis
Inflammation of the prostate gland
Pyelonephritis
Inflammation of the kidney nephron
Urinary tract infection (UTI)
Infection by pathogenic microorganisms of one or more structures if the urinary tract
Bladder UTI signs
Urgency, frequency, pressure, burning pain while urinating, and pain caused by spasm in the region of the bladder and subrapubic area
Most common drugs in treating UTIs
Amoxicillin, trimethoprim, nitrofurantoin, urinary analgesics
Urinary analgesics use
UTIs and long term interstitial cystitis
UTI Drugs MOA
Interfere with bacterial multiplication in the urine
Phenazopyridine MOA
Topical analgesic effect on the lining of the urinary tract.
Phenazopyridine use
UTI
UTI Drugs side effects
Anorexia, nausea, vomiting, diarrhea, abdominal pain, stomatitis, drowsiness, dizziness, headache, blurred vision, weakness and peripheral neuropathy, rash, pruritus, photosensitivity, leg cramps
Nitrofurantoin side effects
Acute and chronic pulmonary reactions
Phenazopyridine side effects
Discolor urine (dark orange to brown)
UTI Drugs contraindications
Pregnancy (cat C), lactation
Nitrofurantoin precautions
Pregnancy (cat B) , cerebral atherosclerosis p, diabetes, glucose-6-phosphate dehydrogenase deficiency
UTI Drugs precautions
Renal or hepatic dysfunction
Methenamine contraindications
Allergy to tartrazine
Menthenamine precautions
Gout
Sulfamethizole interactions
Oral anticoagulants increase risk of bleeding
Nitrofurantoin interactions
Nitrofurantoin absorption decreases with magnesium trisilicate and magaldrate, and anticholinergic increase nitrofurantoin absorption
Fosfomycin interactions
Metoclopramide lowers plasma concentration and urinary tract excretion of fosfomycin
Phenazopyridine restrictions
Shouldn’t be taken for more than 2 days when combined with an antibacterial to treat a UTI
UTI Drugs ex
Amoxicillin, fosfomycin, methenamine, nitrofurantoin, trimethoprim
Urinary analgesics ex
Phenazopyridine, pentosan
