Antifungals And Antiparasitics Flashcards
Candidiasis
Infection if the skin or mucous membrane with the yeast Candida albicans
Cinchonism
Qunidine toxicity or poisoning
Fungicidal
Deadly to fungi
Fungistatic
Pertaining to agents that retard growth of fungi
Fungus
Single cell, colorless plant that lacks chlorophyll, such as yeast or mold
Helminthiasis
Invasion by helminth s (worms)
Mycotic infections
Infections caused by fungi
Parasite
Organism living in or on another organism (host) without contributing to the survival or well being of host
Thrush
Candidiasis of the mouth
Systemic fungal infections
Serious infections that occur when the fungi gain entrance into the interior of the body, can grow in lungs, Braun or GI tract
Where dies candidiasis affect patients
Mouth (thrush), affects women in vulvovaginal area, immunocompromised patients with chronic conditions in the perenium, oral cavity, or systemically
Who is at the highest risk for Candidal infections
Diabetes, pregnant, oral contraceptives, antibiotics, or corticosteroids
Antifungal actions
Fungicidal or fungistatic. Amphotericin B, isavuconazonium, miconazole, nystatin, voriconazole, micafungin, and ketoconazole have an effect on the cell membrane of the fungus
Topical antifungals
Butenafine, ciclopirox, clotrimazole, econazole, efinaconazole, miconazole, naftifine, oxiconazole, sulconazole, tavaborole
Antifungal uses
Superficial and deep fungal infections, systemic infections such as aspergillosis, candidiasis, and cryptococcal menengitis, superficial infections of nail beds, and oral, anal, and vaginal areas
Miconazole
Treats vulvovaginal yeast infections
Vaginal antifungal Drugs
Clotrimazole, miconazole, nystatin, terconazole, tioconazole
Amphotericin B interactions
Corticosteroids increase risk for severe hypokalemia, digoxin increases risk of digitalis toxicity, aminoglycosides increase risk of nephrotoxicity, cyclosporine increases risk of nephrotoxicity, flucytosine causes drug toxicity, and miconazole decreases effectiveness of amphotericin B
Fluconazole interactions
Oral hypoglycemics increase their own effect, phenytoin decreases its own effectiveness
Griseofulvin interactions
Barbiturates decreases their own effect, oral contraceptives decrease their own effectiveness salicylates decrease their own serum level
Itraconazole interactions
Digoxin and cyclosporine elevate blood levels of itraconazole, phenytoin and histamine antagonists decrease blood levels of itraconazole, isoniazid and rifampin decrease blood levels of itraconazole
Ketoconazole interactions
Histamine antagonist and antacids decreases absorption of ketoconazole, rifampin or isoniazid decrease blood levels of ketoconazole
Posaconazole interactions
Cimetidine decreases posaconazole blood levels, phenytoin increases its own effectiveness, rifabutin decrease blood levels of posaconazole, stations increase their own effectiveness
Voriconazole interactions
Methadone, tacrolimusm ,the statins, benzodiazepines, CCB’s increase effectiveness of voriconazole, sulfonylureas cause hypoglycemia, vinca alkaloids increase risk of neurotoxicity
Micafungin interactions
Sirolimus increases risk of immunosuppression, nifedipine increases risk of its own toxicity
Terbinafine interactions
Beta blockers and antidepressants increase their own effectiveness