Cholinergic Blocking Drugs Flashcards
Anticholinergic
Blocks the neurotransmission of the parasympathetic nervous system
Cholinergic blocking
Blocked the effect of the parasympathetic branch of the ANS
Cycloplegia
Paralysis of the ciliary muscle, resulting in an inability to focus the eye
Mydriasis
Dilation of the pupil
Parasympatholytic
Blocking the parasympathetic nervous system
Xerostomia
Drying of oral secretions
Cholinergic blocking drugs MOA
Inhibit activity of acetylcholine at the parasympathetic nerve synapse, so that impulses traveling along the parasympathetic nerve can’t pass from the nerve endings to an organ or structure
Side effects of cholinergic blocking drugs in elderly
Excitement, agitation, mental confusion, drowsiness, urinary retention
Cholinergic blocking drugs uses
Uretersl or biliary Colin and bladder overactivity, pylorospasm, peptic ulcer, vagal nerve induced bradycardia, and Parkinsonism, and preoperative reduction of oral secretions
Severity of adverse reactions of cholinergic blocking drugs is dependent on
Dose
Cholinergic blocking drugs GI side effects
Dry mouth, nausea, vomiting, difficulty swallowing, heartburn, constipation
Cholinergic blocking drugs CNS system side effects
Headache, flushing, nervousness, drowsiness, weakness, insomnia, nasal congestion, fever
Cholinergic blocking drugs visual reactions
Blurred vision, mydriasis, photophobia, cycloplegia, increased ocular tension
Cholinergic blocking drugs genitourinary system side effects
Urinary hesitancy and retention, dysuria
Cholinergic blocking drugs cardiovascular system side effects
Palpitations, Brady cardia (after low doses of atropine), tachycardia (after high doses of atropine)
Cholinergic blocking drugs side effects general
Urticaria, decreased sweat production, anaphylactic shock, rash
Patients taking cholinergic blocking drugs in hot summer months should watch for
Signs of heat prostration (fever, tachycardia, flushing, warm and dry skin, mental confusion)
Cholinergic blocking drugs contraindications
Glaucoma, myasthenia gravis, tachyarrhythmia, myocardial infarction, and heart failure (unless bradycardia is present)
Cholinergic blocking drugs precautions
GI infections, benign prostatic hypertrophy, urinary retention, hyperthyroidism, hepatic or renal disease, and hypertension, pregnancy (cat C)
Atropine precautions
Asthma
Cholinergic blocking drugs interactions
Decreased effectiveness of antibiotics and antifungals, meperidine, flurazepam, phenothiazines and TCAs decrease effect of cholinergic blocker, decrease effectiveness of haloperidol, increased serum levels of digoxin
Cholinergic blocking drugs ex
Atropine, dicyclomine, glycopyrrolate, mepenzolate, methscopolamine, propantheline, scopolamine, trimethobenzamide
Cholinergic blocking urinary antipasmodics ex
Darifenacin, fesoterodine, flavoxate, oxybutynin, solifenacin, tolterodine, trospium
Cholinergic blocking drugs for Parkinson’s disease
Benztropine mesylate, diphenhydramine, trihexyphenidyl
Cholinergic blocking drugs for acute respiratory symptom relief
Aclidinium, ipratropium, tiotroplum, umeclidinium