Antitubercular Drugs Flashcards
Directly observed therapy (DOT)
Drug dose taken in from of the administrator
Extrapulmonary
Occurring outside of the lungs in the respiratory system
Gout
A metabolic disorder resulting in increased levels of Uris acid and causing severe joint pain
Latent TB
Inactive M. tuberculosis bacterium in the body, which is alive, but no infectious and can become active later
Multi drug-resistant M. tuberculosis (MDR-TB)
Bacterium that is resistant to a number of different drugs (can be expensive to treat)
Mycobacterium leprae
Bacterium that causes leprosy (chronic, communicable, disease infrequently seen in the US)
Mycobacterium tuberculosis
Bacterium that causes TB
Optic neuritis
Inflammation of optic nerve, causing a decrease in visual acuity and changes in color perception
Peripheral neuropathy
Numbness and tingling of the extremities
Vertigo
Feeling is a spinning or rotational motion, dizziness
Primary drugs
Provide foundation for treatment
Secondary drugs
Used for MDR-TB (more costly and toxic than primary drugs)
Secondary drugs ex
Certain flouroquinolones such as ciprofloxacin, ofloxacin, and levofloxacin, and rifampin and isoniazid
Anti tubercular MOA
Both bacteriostatic and bactericidal. Usually inhibit bacterial cell wall synthesis to slow multiplication rates
What to give for latent TB therapy
Isoniazid