Transplant

Question 1

define allograft

Answer 1

transplant of one organ or tissue from one individual to another

Question 2

Define isograft

Answer 2

transplanted organ from a genetically identical donor

Question 3

Define autograft

Answer 3

transplant in the same patient

Question 4

Define induction

Answer 4

immunosuppression given prior transplant to prevent acute rejection during early post transplant period by providing high degree of immunosuppression

Question 5

Drug most commonly used for induction

Answer 5

Basiliximab

Question 6

basiliximab MOA

Answer 6

IL-2 receptor antagonist on surface of activated T-lymphocyte

Question 7

If at high risk for rejection another drug to use for induction

Answer 7

antithymocyte globulin

Question 8

ATG MOA

Answer 8

binding to antigens on T-lymphocytes and interfering with their function

Question 9

What drugs are commonly used for maintenance immunosuppression

Answer 9

calcineurin inhibitor
antiproliferative agent
+/- steroids

Question 10

List antiproliferative agents

Answer 10

mycophenolate

azathioprine

Question 11

major SE of tacrolimus

Answer 11

nephrotoxicity
neurotoxicity
hypo/hyperkalemia
QT prolongation

Question 12

list calcineurin inhibitors

Answer 12

tacrolimus

cyclosporine

Question 13

list m-tor inhibitors

Answer 13

everolimus

sirolimus