Drug allergies and ADRs

Question 1

What is a type A reaction

Answer 1

dose-dependent and predicatble based on the drugs pharmacology

Question 2

What is a type B reaction

Answer 2

not dose-dependent are unrelated to the pharmacologic actions and can be influenced by patient-specific factors

Question 3

what is a type 1 allergic reaction

Answer 3

immediate within 15-30 minutes

Question 4

What is a type 2 drug allergy

Answer 4

reacts minutes to hours

Question 5

What is a type 3 drug allergy

Answer 5

occurs 3-10 hours after exposure

Question 6

what is a type 4 drug allergy

Answer 6

delayed hypersensitvity can take from 48 hours to weeks to show up

Question 7

what is a boxed warning

Answer 7

indicates a risk of death or permanent disability

Question 8

key drugs associated with photosensitivity

Answer 8

amiodarone
diuretics-loop and thiazide
mtx
oral and topical retinoids
quinolones
st john's wort
sulfa
tacrolimus
tetracyclines
voriconazole

Question 9

key drugs associated with TTP (thrombotic thrombocytopenia purpura)

Answer 9

clopidogrel

sulfamethoxazole

Question 10

what drugs to avoid in sulfa allergy

Answer 10

sulfasalzaine
sulfadiazine
sulfisoxazole
thiazide diuretics
loop diureteics
acetazolamide
zonisamide
celecoxib
cedofovir

Question 11

drugs to avoid with a peanut or soy allergy

Answer 11

clevidpine
propofol
progesterone

Question 12

drugs to avoid with an egg allergy

Answer 12

clevidipine
propofol
yellow fever vaccine