Benign Prostatic Hyperplasia (BPH)

Question 1

What is DHT and function with BPH

Answer 1

testerosterone is metabolized to dihydrotestosterone by 5-alpha-reductase. DHT is responsible for normal and hyperplastic growth (increase in number of cells). BPH results from overgrowth of the stromal and epithelial cells of the prostate gland

Question 2

Drugs that worsen BPH

Answer 2

anticholinergics
antihistamines
caffeine
decongestants
diuretics
SRNIs
TCAs
testosterone products

Question 3

S/Sx of BPH

Answer 3

hestiancy, straining or weak stream

urgency, leaking

Question 4

natural products for BPH

Answer 4

saw palmetoo

pygeum

Question 5

Treatment for BPH

Answer 5

alpha blockers
5-alpha-reductaseinhibitor
-do not use if there is not enlarged prostate
tadalafil + finasteride

Question 6

5-alpha-reductase MOA

Answer 6

decreasing size of prostate

Question 7

Alpha blockers MOA

Answer 7

inhibit alpha-1 adrenergic receptors and relax the smooth muscle of the bladder neck, reducing bladder outlet obstruction and improving urinary flow

Question 8

List Alpha blockers

Answer 8

non selective
-terazosin
-doxazosin
selective alpha-1A (primary type in prostate)
-tamsulosin

Question 9

Major warning for alpha blockers

Answer 9

intraoperative floppy iris syndrome

Question 10

List 5-alpha reductase inhibitors

Answer 10

finasteride

Question 11

5-alpha reductase inhibitors MOA

Answer 11

inhibit the 5-alpha reductase enzyme which blocks the conversion of testosterone to dihydrotestosterone