Inflammatory bowel disease

Question 1

IBD and IBS difference

Answer 1

IBD causes inflammation IBS does not

Question 2

Induction of remission for chron’s treatment options

Answer 2

steroids +/- thiopurine or mtx
anti-TNF +/- thiopurine
interleukin receptor antagonist

Question 3

Induction of remission for ulcerative colitis treatment options

Answer 3

5-ASA +/- steroids or thiopurine
anti-TNF +/- thiopurine
IV cyclosporine
tofacitinib

Question 4

Chrohn’s maintenance

Answer 4

mild disease
-oral budesonide for < 3 months followed by thiopurine or mtx
mod-severe disease
-anti-TNF
--adalimumab
--infliximab
--certolizumab
-thiopurine
-mtx
-IL receptor antagonist
--ustekinumab
refractory 
-integrin receptor antagonist
--vedolizumab
--natalizumab

Question 5

Ulcerative colitis maintenance tratment

Answer 5

mild
-mesalamine (5-ASA)
mod-severe
-anti-TNF
--adalimumab
--infliximab
--golimumab
-thiopurine
-cyclosporine
-janus kinase inhibitor
--tofacitinib
refractory
-integrin receptor antagnoist
--vedolizumab