Gastroesophageal reflux disease & Peptic ulcer disease

Question 1

GERD is a result of what body function

Answer 1

reduced lower esophageal sphincter pressure (muscle tone) and gastric contents can backflow into the esophagus

Question 2

Drugs that worsen GERD

Answer 2

NSAIDs
Bisphosphonates
Estrogen products
Fish oil
Iron supplements
NRT
Steroids
Tetracyclines

Question 3

Brand name for ca carbonate + magnesium

Answer 3

Mylanta

Question 4

Brand name for ca carbonate + simethicone

Answer 4

Maalox

Question 5

Warning for antacids

Answer 5

if product contains Al and Mg they can accumulate with severe renal dysfunction

Question 6

List histamine receptor antagonists

Answer 6

famotidine
ranitidine
cimetidine

Question 7

Warning for H2RAs

Answer 7

confusion-reversible risk factor is elderly, severely ill, renal impairment

Question 8

Which PPIs can be taken without regards to meals

Answer 8

Dexlansoprazole

pantoprazole

Question 9

Warnings for PPIs

Answer 9

Cdif
hypomagnesemia
osteoporosis related fractures

Question 10

which PPIs are available Iv

Answer 10

pantoprazole

esomeprazole

Question 11

metoclopramide MOA

Answer 11

Da agonist and enhances response to ach in the upper GI causing enhanced motility and accelerated gastric emptying and increased LES

Question 12

3 main causes of peptic ulcers

Answer 12

H. pylori
NSAIDs
stress ulcers- in ventilated pt

Question 13

Treatment for peptic ulcer

Answer 13

bismuth subsalicylate +
metronidazole +
tetracycline +
PPI BID

Question 14

Misoprostol MOA

Answer 14

prostaglandin E1 analog