Overactive Bladder

Question 1

S/Sx of OAB

Answer 1

urgency
frequency: > 8 times
Nocturia
incontinence

Question 2

Urinary incontinence due to urge cause

Answer 2

associated with neuropathy

Question 3

detrusor muscle

Answer 3

with the bladder outlet functions are neurologically coordinated to store and expel urine

Question 4

How is the detrusor muscle innervated

Answer 4

via the parasympathetic system (acetylcholine actin on muscarinic receptors)

Question 5

Define OAB

Answer 5

inappropriate stimulation of the muscarinic receptors on the detrusor muscle causing involuntary contractions and feeling of urinary urgency

Question 6

Of the 3 muscarinic receptors in the bladder which is responsible for both emptying contractions as well as involuntary bladder contractions

Answer 6

M3

Question 7

Treatment of OAB

Answer 7

first-line
-kegals
second-line
-anticholinergic drugs
-beta-3 receptor agonists

Question 8

List anticholinergics for OAB

Answer 8

oxybutynin

solifenacin

Question 9

Contraindication for anticholinergics

Answer 9

narrow angle glaucoma

Question 10

beta-3 agonist MOA

Answer 10

relaxes teh detrusor muscle and increases bladder capacity by activating beta-3 receptors

Question 11

List a beta-3 agonist

Answer 11

mirabegron

Question 12

first line medication for nocturia

Answer 12

desmopressin

Question 13

desmopressin MOA

Answer 13

antidiuretic hormone to decrease urine production