Gout

Question 1

Define gout

Answer 1

type of arthritis caused by a buildup of uric acid crystals primarily in the joints. UA is produced as an end-product of purine metabolism. purines are present in many foods, and they make up one of the base pairs of DNA

Question 2

normal serum UA

Answer 2

2-6.5 mg/dL in females

3.5-7.2 mg/dL in males

Question 3

foods to avoid in gout

Answer 3

organ meats
high-fructose corn syrup
alcohol

Question 4

What goal UA do drugs target

Answer 4

<6 mg.dL

Question 5

drugs that increase UA

Answer 5

ASA
diuretics
niacin
pyrazinamide
pancreatic enzyme products
CNIs
chemotherapy

Question 6

Acute gout treatment

Answer 6

NSAID
systemic steroid
cholchicine

Question 7

ppx for gout

Answer 7

xanthine oxidase inhibitors

• allopurinol
• febuxostat

Question 8

define tophi

Answer 8

UA crystals that form under the skin in long-term gout

Question 9

Important point to remember for allopurinol

Answer 9

Asians should be screened for HLA-B*5801 allele for hypersensitivity reactions

Question 10

MOA of allopurinol

Answer 10

decrease uric acid production

Question 11

drugs used for chronic urate lowering therapy

Answer 11

xanthine oxidase inhibitors
uricosurics
recombinant uricase

Question 12

list uricosurics

Answer 12

lesinurad

probenacid

Question 13

uricosurics MOA

Answer 13

inhibit reabsorption of uric acid in the kidneys which increase uric acid excretion

Question 14

recombinant uricase MOA

Answer 14

convert uric acid to allantoin which is excreted

Question 15

list recombinant uricase

Answer 15

pegloticase