Thyroid Disorders Flashcards
What is T3 name
triiodothyronine
what is T4 name
Thyroxine
What stimulates the production of thyroid hormone
the pituitary gland release TSH which stimulates the thyroid
which form of thyroid is unbound and active
T4
Define Hasimoto’s disease
autoimmune condition in which a patient’s own antibodies attack the thyroid gland causing hypothyroidism
Define myxedema coma
potentially fatal complication of hypothyroidism that can occur when hypothyroidism is left untreated for a long time
S/Sx of hypothyroidism
cold intolerance dry skin fatigue weight gain goiter
Key drugs that can cause hypothyroidism
"I TALC" interferons tyrosine kinase inhibitors amiodarone lithium carbamazepine
DOC for hypothyroidism
Levothyroxine (T4)
treatment for hypothyroidism
levothyroxine (T4)
liothyronine (T3)
desiccated thyroid (T3&4)
levothyroxine dose
1.6 mcg/kg/day
Define grave’s disease
common cause of hyperthyroidism
autoimmune disorder that the antibodies stimulate the thyroid to produce too much T4
Drugs that cause hyperthyroidism
iodine
amiodarone
interferons
S/Sx of hyperthyroidism
weight loss
agitation/anxiety
palpitations
Hyperthyroidism treatment
radioactive iodine-destroy part of the gland
beta blockers-symptoms relief
Thionamides
iodides
Hyperthyroidism in pregnancy
PTU for 1st trimester
methimazole for 2nd and 3rd trimester
DOC for thyroid storm
PTU
List thionamides
propylthiouracil (PTU)
methimazole
MOA of thinamides
inhibit synthesis of thyroid hormones by blocking the oxidation of iodine in the thyroid gland
List iodides
potassium iodide
MOA of iodides
temporarily inhibit secretion of thyroid hormones
potassium iodide and radioactive iodine for hyperthyroidism
potassium iodide should be taken ASAP after radiation to prevent thyroid cancer
Define thyroid storm
decompensated hyperthyroidism
S/Sx of thyroid storm
Fever tachycardia profuse sweating agitation delirum coma psychosis
Treatment for thyroid storm
PTU inorganic iodide therapy beta blockers systemic steroid aggressive cooling
