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NAPLEX > Systemic steroids & Autoimmune conditions > Flashcards

Systemic steroids & Autoimmune conditions Flashcards

1
Q

fludrocortisone mimic?

A

aldosterone

has mineralocorticoid activity

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2
Q

mineralocorticoid activity is?

A

maintain balance of water and electrolytes

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3
Q

Glucocorticoid activity

A

anti-inflammatory effects

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4
Q

Define HPA axis suppression

A

systemic steroids can cause the adrenal gland to stop producing cortisol due to feedback inhibition
-reason why steroids need to be tapered off so adrenal gland can resume cortisol production

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5
Q

Define Cushing’s syndrome

A

the adrenal gland produces too much cortisol or when exogenous steroids are taken in high doses and amount of cortisol produced is higher than what would have been produced naturally

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6
Q

Deffine Addison’s disease

A

adrenal gland is not making enough cortisol

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7
Q

S/Sx of cushing’s

A 
psych changes
achne
GI bleeding
DM
hirsutism
poor bone health
infections
growth retardation
striae
moon face
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8
Q

Steroids least potent to most potent

A 
"Cute Hot Pharmacists and Physicians Marry Together & Deliver Babies"
Cortisone
Hydrocortisone
Prednisone
Prednisolone
Methylprednisolone
Triamcinolone
Dexamethasone
Betamethasone
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9
Q

What dose of steroids cause immunosuppression

A

> 2mg/kg/day or >20mg/day of prednisone

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10
Q

how to identify RA versus OA

A

bilateral, symmetrical disease where OA presents unilaterally

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11
Q

S/Sx of RA

A

joint swelling
pain-worse after rest
stiffness-worse after rest
bone deformity

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12
Q

preferred initial tx for RA

A

mtx

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13
Q

treatment for RA

A

DMARD
steroids
mtx 1st line
anti-TNF are add on therapy

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14
Q

list non-biologic traditional DMARDS

A 
mtx
hydroxychloroquine
sulfasalazine
leflunomide
tofacitinib
baricitnib
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15
Q

List anti-TNF biologic DMARDs

A 
Etanercept
adalimumab
infliximab
certolizumab
golimumab
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16
Q

S/Sx of Systemic lupus erthematosus

A 
fatigue
depression
anorexia
weight loss
muscle pain
discoid rash
malar rash (butterfly)
photosensitivity
joint pain/stiffness
17
Q

drugs that cause DILE

A 
methimazole
prophylthiouracil
methyldopa
minocycline
procainamide
hydralazine
anti-tnf agnets
terbinafine
isonazid
quinidine
"My Pretty Malar Marking Probably Has A TransIent Quality"
18
Q

Define multiple sclerosis

A

chronic, progressive autoimmune disease in which the patient’s immune system attacks the myelin sheath thus the nerves can no longer properly conduct electrical impulses

19
Q

Treatment for MS

A

Interferon beta

glatiramer acetate

20
Q

S/Sx of myasthenia gravis

A

changes to eyes/vision
drooping eyelid
problem with chewing/swallowing

21
Q

treatment for myasthenia gravis

A

pyidostigmine

NAPLEX (65 decks)

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