Pain Flashcards
Define nociceptive pain
sensory nerves (nociceptors) identify tissue damage. injured tissues releases substances such as prostaglandins, substance P, and histamine which stimulate the nociceptors to send impulses to the brain that result in feeling pain
inhibition of which Cox enzyme results in less GI bleeding
Cox 2
ASA MOA
irreversible cox-1 inhibitor and antiplatelet
List non-selective Cox1/2 inhibitors
ibuprofen
indomethacin
naproxen
ketorolac
List Cox2 selective inhibitors
Celecoxib
diclofenac
meloxicam
opioids MOA
mu receptor agonist
when can a patient be transitioned to fentanyl patches
using morphine 60 mg/day or equivalent for at least 7 days
methadone boxed warning
QT prolongation
meperidine brand name
demerol
the common drugs in the same chemical class that cross-react with each other what what in the name
cod or morph
- codeine
- hydrocodone
- oxycodone
- morphine
- hydromorphone
- oxymorphone
- buprenorphine
- heroin
treatment for opioid induced constipation
stimulant laxative DOC
methylnaltrexone
naloxegol
tramadol MOA
mu-opioid receptor antagonist and inhibitor of NE
warning for tramadol
sizure risk
serotonin syndrome
Risk factor for opioid induced respiratory depression
history of previous OD substance abuse large dose > 50 mg MOE use with bzd comorbid illness
buprenorphine MOA
partial mu-opioid agonist
agonist at low dose and antagonist at high doses
