Thyroid and antithyroid agents Flashcards
where does thyroid hormone synthesis take place?
cell itself and colloid
how does iodide get into the thyroid gland?
sodium / iodide symporter (NIS)
what enzyme is responsible for converting iodide to iodine?
peroxidase
what is iodide organification? what are the results?
iodination of tyrosine residues within thyroglobulin molecule
monoiodotyrosine (MIT)
diiodotyrosine (DIT)
how are the thyroid hormones formed?
molecules of MIT and DIT are combined to form:
MIT plus DIT - T3
DIT plus DIT - T4
what is the typical ratio of thyroid hormones?
T4: T3 - 5:1
the majority of thyroid hormones are bound to what molecule?
thyroxine bound globulin (TBG)
what is the MOA of thyroid hormone in the absence of thyroid hormone?
homodimer of receptor is sitting on response element of gene - NO activation of transcriptional processes
what is the MOA of thyroid hormone in presence of thyroid hormone?
hormone is transported into cell
RXR and TR form heterodimer and increases gene transcription
what is the function of 5’-deiodinase (5’-DI)?
conversion of T4 to T3
what is the result of inhibition of 5’-DI?
hypothyroidism type symptoms
what is the regulation of thyroid secretion? what type of feedback is involved?
TRH - TSH
TSH promotes synthesis of T4 and T3
negative feedback
what are the result of high blood concentrations of iodide on hormone synthesis? low blood levels?
inhibition
promotion of synthesis
what are the metabolic effects of thyroid hormone on fat?
- decrease circulating cholesterol via increase in LDLr expression
- increased lipolysis
what are the metabolic effects of thyroid hormone on carbohydrates?
- increased intestinal absorption of carbohydrates
- increased glycolysis
- increased gluconeogenesis
- increased insulin secretion
what are the metabolic effects of thyroid hormone on protein?
increased protein synthesis and catabolism
what are the metabolic effects of thyroid hormone on vitamins?
increase need and usage for cofactors to enzymes as a result of a general increase in enzyme secretion
definition: myxedema
when is it seen in relation to thyroid metabolism?
puffy, baggy eyes from retention of fluids in interstitial spaces
hypothyroidism