Antibiotics IIa Flashcards
penecillins target what bacterial cell component / process?
cell wall synthesis
cephalosporins target what bacterial cell component?
cell wall synthesis
monobactams target what bacterial cell component / process?
cell wall synthesis
glycopeptides target what bacterial cell component / process?
cell wall synthesis
polypeptides target what bacterial cell component / process?
cell wall synthesis
carbapenems target what bacterial cell component / process?
cell wall synthesis
phosphoenolpyruvates target what bacterial cell component / process?
cell wall synthesis
lipopeptides target what bacterial cell component / process?
cell membrane
detergents target what bacterial cell component / process?
cell membrane
tetracyclines target what bacterial cell component / process?
protein synthesis
aminoglycosides target what bacterial cell component / process?
protein synthesis
macrolides target what bacterial cell component / process?
protein synthesis
sulfonamides target what bacterial cell component / process?
folate synthesis inhibitors / gyrase inhibitors / DNA damage
what are important enzymes in bacterial cell wall building process?
peptidoglycan binding proteins
what is the function of the PBPs?
create bond between NAM-NAG peptidoglycan monomers and NAM-NAG chains
what are the beta lactam compounds?
penicillins
cephalosporins
monobactams
carbapentems
what is the MOA of beta lactam compounds?
bind to and inhibit the PBP enzymes
what is the main adverse effect of beta lactam compounds?
hypersensitivity
more severe hypersensitivity to beta lactam abx would contraindicate use of what other abx?
….beta lactams
penicillin G and V are narrow or broad spectrum?
narrow
ampicillin and amoxicillin are narrow or broad spectrum?
broad
what is the role of clavulanic acid? what is the clinical use?
beta lactamase inhibitor
given in combination with penicillins to increase efficacy
what is the MOA for cephalosporins?
bind to and inhibit PBPs
what is the main adverse effect of cephalosporins?
hypersensitivity
increasing generations of cephalosporins have narrower or broader spectrum?
broader