Cardiovascular pharmacology XI

Question 1

what are the adverse effects of digoxin?

Answer 1

1. electrolyte disturbances and acid-base disbalance
2. arryhthmias
3. anorexia, nausea, vomiting

Question 2

what are the clinical applications for digoxin?

Answer 2

heart failure, especially CHF with AF

Question 3

what is used to correct digoxin toxicity?

Answer 3

1. cholestyramine

2. digoxin immune Fab

Question 4

what is the MOA of the PDE3 inhibitors?

Answer 4

increase in cAMP concentration by inhibiting PDE3 - which normally degrades cAMP

Question 5

what are the CV effects of PDE3 inhibitors?

Answer 5

1. direct myocardial stimulation
2. accelerate myocardial relaxation
3. balanced arterial and venous dilation
4. all leading to increased CO

Question 6

what are the therapeutic uses for PDE3 inhibitors?

Answer 6

short term circulation support in advanced CHF