Estrogens and progestins Flashcards
steroidogenesis in the ovary is regulated by what compounds?
LH and FSH (gonadotropins)
which cells are required for estradiol synthesis?
theca and granulosa
what are the features of follicular phase of ovarian cycle?
- high frequency, low amplitude LH secretion
- estrogen rises
- endometrial proliferation
what is the main feature of ovulation? which day does it occur?
estrogen induced gonadotropin surge
day 14
what are the features of the luteal phase of the ovarian cycle?
- rise in estrogen and progesterones
2. endometrial differentiation under control of progesterone
which hormone is absolutely required for ovulation?
LH
what is the effect of estrogen on the endometrium?
endometrial proliferation
what is the effect of progesterone on the endometrium?
endometrial differentiation
preparation for implantation
decrease uterine contractions
how does progesterone influence glucose metabolism?
leads to glucose intolerance
which hormone is the key regulator during the luteal phase of the menstrual cycle?
progesterone
which hormone is the key regulator during the follicular phase of the menstrual cycle?
estrogen
what are the effects of estrogen on lipids?
decrease LDL
increase HDL
increase TGs
what is the effect of estrogen on bone?
antiresorptive
what is the effect of estrogen on the liver?
increase plasma proteins
what are the effects of estrogen on the blood?
increase coag factors
decrease antithrombin