Autonomic pharmacology I Flashcards
which organs receive only sympathetic innervation?
- hair follicles
- thermoregulatory sweat glands
- liver
- adrenal glands
- kidney
all preganglionic fibers secrete which NT?
Ach
which enzyme is responsible for brining choline into the nerve terminal?
CHT
which drug blocks entry of choline into the nerve terminal?
hemicholiniums
which enzyme is responsible for brining Ach into the vesicle?
VAT
which enzyme is responsible for forming Ach from AcCoA and choline?
ChAT
which drug blocks entry of Ach into the vesicle?
vesamicol
which enzymes are responsible for fusion of vesicle to the nerve terminal membrane?
VAMPs
what is the function of neostigmine?
Anticholinesterase - increases Ach in synapse and thus PNS function
what is the function of tubocurarine?
neuromuscular blocking agent - cholinoceptor antagonist
which receptor is found on the dilator (radial) muscle of the iris?
a1
which receptor is found on the constrictor (sphincter) muscle of the iris?
M3
which receptors are found on the ciliary muscle?
M3, B2
which receptors are found on the ciliary body epithelium?
a2, B1, B2
what is the result of M3 receptor activation in the eye?
- constriction of sphincter pupillae muscle
- contraction of ciliary muscle (relaxation of lens)
- opening of Canal of Schlemm